Evaluation of the Effect of Triamcinolone at Different Doses on LIA During TKA
Key facts
- Who runs it
- Peking University Third Hospital
- Where
- China1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- Phase
- Phase 4
- People taking part
- 120 people enrolled
- Started
- 25 Apr 2023
- Ended
- 1 May 2024
- Type of study
- Interventional, 4 groupsOne group gets a placebo (a dummy treatment), for comparison.
- Treatments tested
- without triamcinolone
- 20mg triamcinolone
- 40mg triamcinolone
- 80mg triamcinolone
- Record updated
- 15 October 2026
Who can take part
- Age
- 50 years to 85 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 10 criteriaShow less
Who can take part
- age in the range of 50 to 85 years old
- patients with knee osteoarthritis requiring primary unilateral total knee replacement
- the body mass index in the range of 18 to 36 kg/m2
- possess the physical status I-III of American Society of Anesthesiologists
- the patient and his family members agree and sign the informed consent
Who cannot take part
- Patients who had used glucocorticoids within 3 months before surgery
- History of knee surgery or knee injury, such as high tibial osteotomy, meniscus repair, ligament reconstruction, etc
- People allergic to the drugs used in this study
- Non-osteoarthritis (rheumatoid arthritis, traumatic arthritis, septicemic arthritis, etc.)
- Flexion deformity ≥30°, internal and external varus deformity ≥15°
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
To evaluate the efficacy and safety of different doses of triamcinolone for local infiltration analgesia during total knee replacement
The 4 groups in the trial
- PlaceboPlacebo, for comparison
LIA preparation was administered without triamcinolone. The base formula contains 150mg ropivacaine and 0.5mg epinephrine. Add normal saline and mix to 80ml.
Treatment: without triamcinolone
- Low dose triamcinoloneTreatment being tested
Add 20mg triamcinolone to the LIA preparation. The base formula contains 150mg ropivacaine and 0.5mg epinephrine. Add normal saline and mix to 80ml.
Treatment: 20mg triamcinolone
- Moderate dose triamcinoloneTreatment being tested
add 40mg triamcinolone to the LIA preparation. The base formula contains 150mg ropivacaine and 0.5mg epinephrine. Add normal saline and mix to 80ml.
Treatment: 40mg triamcinolone
- High dose triamcinoloneTreatment being tested
add 80mg triamcinolone to the LIA preparation. The base formula contains 150mg ropivacaine and 0.5mg epinephrine. Add normal saline and mix to 80ml.
Treatment: 80mg triamcinolone
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Evaluation of the Effect of Triamcinolone at Different Doses on Local Infiltration Anesthesia During Total Knee Arthroplasty
- Record updated
- 15 October 2026