Studies how fitness relates to mouth bacteria and muscle blood flow
Looks at how fitness, mouth bacteria and blood flow to muscle are linked in adults.
Plain-language title generated from the registry record
Registry title: Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status
Key facts
- Where
- Charlottesville, United StatesSee the site
Where in United States
- UVA Student Health and Wellness BuildingCharlottesville, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Virginia
- Trial code
- NCT06009276
- Record updated
- 24 December 2025
- Original description
The purpose of the study is to determine associations between fitness status, bacteria in the mouth, and the blood flow to muscle. This study is trying to find out if fitness status impacts the bacteria that are present in the oral microbiome (environment in the mouth) or the ability of the body to send blood to the skeletal muscle.Read full original descriptionShow less
Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status
The purpose of the study is to determine associations between fitness status, bacteria in the mouth, and the blood flow to muscle. This study is trying to find out if fitness status impacts the bacteria that are present in the oral microbiome (environment in the mouth) or the ability of the body to send blood to the skeletal muscle.
Participants will complete all or some of the following:
* A mouth swab to assess the bacteria in their mouths. * Produce a saliva sample into a tube. * Cycle on a bike until you reach maximum effort. * Undergo blood draws * Wear a 24-hour non-invasive device that monitors blood pressure. * Drink 70mL (1/3 of a cup) of concentrated beetroot juice once
Inclusion: Subjects must be able to communicate meaningfully with the investigator and must be legally competent to provide written informed consent; Subjects may be of either sex with age 18 years.
Exclusion: Oral antibiotic use within previous four weeks; Subjects taking nitroglycerine (or inorganic nitrates), PDE-5 inhibitors (ex: Cialis, Viagra), and xanthine oxidase inhibitors (ex: Allopurinol); Oral disease or poor oral health as determined by the Oral Health Questionnaire; Hypersensitivity to any ultrasound contrast agent; Diagnosis of chronic renal failure (GFR < 60 ml/min/1.73m); Using an antibacterial mouthwash or a mouthwash containing chlorhexidine and unwilling to discontinue use; Tobacco smokers; Pregnant or lactating females; Inability to perform exercise; Unable to communicate effectively in English to the study team.