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WithdrawnNo phase

Koebner's Phenomenon in Psoriasis and Lichen Planus

Key facts

Who runs it
Marie-Charlotte Brüggen
Trial code
Status
Withdrawn
Started
1 Sept 2025
Ended
20 Sept 2025
Type of study
Interventional
Treatments tested
  • Tape stripping
Record updated
17 March 2026
Why it stopped
due to personnel and financial restrictions, the study could not be conducted

Who can take part

Age
18 years to 70 years
Sex
Women and men
Healthy volunteers
Can take part

The registry criteria, word for word

Show all 12 criteriaShow less

Who can take part

  • Dermatologist diagnosed psoriasis (group psoriasis), lichen planus (group lichen planus) or no skin disease (group healthy controls)
  • Subject is capable of giving informed consent
  • Signed informed consent

Who cannot take part

  • Known or suspected non-compliance, drug or alcohol abuse,
  • Previous enrolment into the current study,
  • Active or recurrent serious bacterial, fungal or viral infection at the time of enrollment by patient history, including patients with Human Immunodeficiency Virus (HIV) infection, Hepatitis B and Hepatitis C infection, active or untreated latent tuberculosis
  • Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant,
  • Use of systemic immunosuppressive/immunmodulating agents in the last three months
  • Use of topical anti-inflammatory treatment in the last 7 days in the area of sampling
  • Phototherapy in the last 4 weeks
  • Female patients of childbearing potential who are pregnant or breast feeding or planning a pregnancy during the duration of the trial and/or not practicing acceptable birth control for the duration of the trial
  • Enrolment of the investigator, his/her family members, employees and other dependent persons

About the trial

What the trial wants to find out

Psoriasis and lichen planus often occur at mechanically irritated skin sites (e.g. tight clothing). The investigators would like to investigate this phenomenon in more detail in this study. For this purpose, the skin is specifically irritated at a small and cosmetically favorable site by tearing off scotch tape or rubbing with a wooden spatula. In order to be able to examine the inflammatory processes caused by the irritation more closely, a small skin sample and a skin swab are taken from the irritated area. This skin sample and the swab are repeated after three and fourteen days.

The group in the trial

  • Tape strippingTreatment being tested

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
A Prospective Study to Investigate the Pathophysiology of the Koebner's Phenomenon in Psoriasis and Lichen Planus
Record updated
17 March 2026