Short One-Month Treatment to Prevent Active Tuberculosis in Close Contacts
Tests a short one-month drug course against standard treatment for latent tuberculosis in young people.
Plain-language title generated from the registry record
Registry title: A Novel Therapy With a 1-Month Ultrashort Regimen to Halt Progression From Latent Infection to Active Tuberculosis Among Close Contacts (The TB-YOUTH Study)
Key facts
- Where
- Anshun, Bijie, Dalian, Daozhen Klau and Hmong Autonomous County in Zun'yi, Guiyang, Liupanshui, Qiandongnan Miao and Dong Autonomous Prefecture, Qiandongnan Miao and Dong Autonomous Region, Qiannan, Shanghai, Tongren, and Zunyi, ChinaSee the 64 sites
- Phase
- Phase 3
Where in China
- People's Hospital of GuanlingAnshun, ChinaTaking people
- People's Hospital of Pingba DistrictAnshun, ChinaTaking people
- People's Hospital of PudingAnshun, ChinaTaking people
- People's Hospital of Xixiu DistrictAnshun, ChinaTaking people
- People's Hospital of ZhenningAnshun, ChinaTaking people
- People's Hospital of ZiyunAnshun, ChinaTaking people
- 3rd People's Hospital of BijieBijie, ChinaTaking people
- People's Hospital of Dafang TownBijie, ChinaTaking people
- People's Hospital of HezhangBijie, ChinaTaking people
- People's Hospital of NayongBijie, ChinaTaking people
- People's Hospital of QianxiBijie, ChinaTaking people
- People's Hospital of WeiningBijie, ChinaTaking people
- People's Hospital of ZhijinBijie, ChinaTaking people
- Dalian Public Health Clinical CenterDalian, ChinaTaking people
- People's Hospital of Daozhen Klau and Hmong autonomous countyDaozhen Klau and Hmong Autonomous County in Zun'yi, ChinaTaking people
- Chinese Medicine Hospital of QingzhenGuiyang, ChinaTaking people
- Guiyang Public Health Treatment CenterGuiyang, ChinaTaking people
- People's Hospital of Baiyun DistrictGuiyang, ChinaTaking people
- People's Hospital of Huaxi DistrictGuiyang, ChinaTaking people
- People's Hospital of KaiyangGuiyang, ChinaTaking people
- People's Hospital of Wudang DistrictGuiyang, ChinaTaking people
- People's Hospital of XifengGuiyang, ChinaTaking people
- People's Hospital of XiuwenGuiyang, ChinaTaking people
- Liuzhi Special DistrictLiupanshui, ChinaTaking people
- People's Hospital of PanzhouLiupanshui, ChinaTaking people
- People's Hospital of Shuicheng District, Liupanshui CityLiupanshui, ChinaTaking people
- Second People's Hospital of Liupanshui CityLiupanshui, ChinaTaking people
- Third People's Hospital of LiupanshuiLiupanshui, ChinaTaking people
- People's Hospital of CengongQiandongnan Miao and Dong Autonomous Prefecture, ChinaTaking people
- People's Hospital of CongjiangQiandongnan Miao and Dong Autonomous Prefecture, ChinaTaking people
- First People's Hospital of KailiQiandongnan Miao and Dong Autonomous Region, ChinaTaking people
- People's Hospital of DanzhaiQiandongnan Miao and Dong Autonomous Region, ChinaTaking people
- People's Hospital of HuangpingQiandongnan Miao and Dong Autonomous Region, ChinaTaking people
- People's Hospital of JianheQiandongnan Miao and Dong Autonomous Region, ChinaTaking people
- People's Hospital of JinpingQiandongnan Miao and Dong Autonomous Region, ChinaTaking people
- People's Hospital of LeishanQiandongnan Miao and Dong Autonomous Region, ChinaTaking people
- People's Hospital of LipingQiandongnan Miao and Dong Autonomous Region, ChinaTaking people
- People's Hospital of MajiangQiandongnan Miao and Dong Autonomous Region, ChinaTaking people
- People's Hospital of RongjiangQiandongnan Miao and Dong Autonomous Region, ChinaTaking people
- People's Hospital of SansuiQiandongnan Miao and Dong Autonomous Region, ChinaTaking people
- People's Hospital of ShibingQiandongnan Miao and Dong Autonomous Region, ChinaTaking people
- People's Hospital of TaijiangQiandongnan Miao and Dong Autonomous Region, ChinaTaking people
- People's Hospital of TianzhuQiandongnan Miao and Dong Autonomous Region, ChinaTaking people
- People's Hospital of ZhenyuanQiandongnan Miao and Dong Autonomous Region, ChinaTaking people
- First People's Hospital of FuquanQiannan, ChinaTaking people
- People's Hospital of ChangshunQiannan, ChinaTaking people
- People's Hospital of LiboQiannan, ChinaTaking people
- People's Hospital of LuodianQiannan, ChinaTaking people
- Huashan HospitalShanghai, ChinaTaking people
- People's Hospital of Wanshan DistrictTongren, ChinaTaking people
- Guizhou Aerospace HospitalZunyi, ChinaTaking people
- People's Hospital of Bozhou DistrictZunyi, ChinaTaking people
- People's Hospital of ChishuiZunyi, ChinaTaking people
- People's Hospital of FenggangZunyi, ChinaTaking people
- People's Hospital of Honghuagang DistrictZunyi, ChinaTaking people
- People's Hospital of MeitanZunyi, ChinaTaking people
- People's Hospital of RenhuaiZunyi, ChinaTaking people
- People's Hospital of SuiyangZunyi, ChinaTaking people
- People's Hospital of TongziZunyi, ChinaTaking people
- People's Hospital of Wuchuan Klau and Hmong autonomous countyZunyi, ChinaTaking people
- People's Hospital of XishuiZunyi, ChinaTaking people
- People's Hospital of YuqingZunyi, ChinaTaking people
- People's Hospital of ZhenganZunyi, ChinaTaking people
- Zunyi Infectious Disease HospitalZunyi, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Huashan Hospital
- Trial code
- NCT06022146
- Record updated
- 14 July 2026
- Original description
This is a prospective, multi-center, open-label, cluster randomized controlled clinical trial conducted in school settings to estimate the non-inferiority effect of 1H3P3 compared with 3HR.Read full original descriptionShow less
A Novel Therapy With a 1-Month Ultrashort Regimen to Halt Progression From Latent Infection to Active Tuberculosis Among Close Contacts (The TB-YOUTH Study)
This is a prospective, multi-center, open-label, cluster randomized controlled clinical trial conducted in school settings to estimate the non-inferiority effect of 1H3P3 compared with 3HR.
Inclusion: Aged ≥13 years and body weight ≥ 30 kg; School-registered individuals including:; Currently attending junior / senior high school or university students; School staff members; Close contacts of active pulmonary TB index cases (confirmed or clinically diagnosed) within the school, defined by meeting both of the following:; Teachers/students sharing the same classroom or dormitory with the index case; Exposure history: Prolonged sharing of enclosed space (>4 hours total within 1 week) with the index case; Confirmed LTBI status through screening; Voluntary participation with signed informed consent form (for adults ≥18 years); Parental / guardian consent and co-signed informed consent form (for minors aged 13-17 years).
Exclusion: Prior completion of full-course of treatment for ATB or LTBI; Current receiving immunosuppressive therapy or biological agents; Current active TB disease (clinically or bacteriologically confirmed); Documented isoniazid/rifampicin resistance in the corresponding M. tuberculosis strain from the index case; Hypersensitivity or intolerance to rifamycins (rifapentine / rifampicin) or isoniazid; HIV positive serostatus or AIDS patients; History of viral hepatitis (e.g., chronic hepatitis B, chronic hepatitis C) or liver cirrhosis; Other conditions deemed unsuitable for TPT by investigators; Liver dysfunction (TBil>2.5mg/dL [43umol/L] or ALT / AST>2ULN) or renal dysfunction; Hematologic disorders with either PLT<50×109/L or WBC<3.0×109/L; Self-reported use of rifamycins (e.g., rifampicin, rifapentine) or isoniazid for >14 consecutive days within the past 2 years.