Studying blood flow and leg muscle fatigue in people after stroke
Tests ischemic conditioning, a simple non-invasive procedure, in stroke survivors to study leg muscle fatigue.
Plain-language title generated from the registry record
Registry title: Blood Flow Regulation and Neuromuscular Function Post-Stroke
Key facts
- Where
- Milwaukee, United StatesSee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 85 years old?
Source: NCT06027294, who can take part
Where in United States
- Marquette UniversityMilwaukee, United StatesTaking people
- Medical College of WisconsinMilwaukee, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Medical College of Wisconsin
- Trial code
- NCT06027294
- Record updated
- 25 September 2025
- Original description
The muscles of stroke survivors can fatigue faster compared to muscles in people who have not had a stroke, which can limit how long a person with stroke can perform tasks such as walking. This study will examine how blood flow is regulated to the exercising leg muscle post-stroke, because if the muscle does not receive enough blood flow it will become fatigued. Finally, the investigators will use a safe and simple non-invasive intervention called ischemic conditioning, which has known effects to improve blood flow to exercising muscle and determine the effects on muscle fatigue.Read full original descriptionShow less
Blood Flow Regulation and Neuromuscular Function Post-Stroke
The muscles of stroke survivors can fatigue faster compared to muscles in people who have not had a stroke, which can limit how long a person with stroke can perform tasks such as walking. This study will examine how blood flow is regulated to the exercising leg muscle post-stroke, because if the muscle does not receive enough blood flow it will become fatigued. Finally, the investigators will use a safe and simple non-invasive intervention called ischemic conditioning, which has known effects to improve blood flow to exercising muscle and determine the effects on muscle fatigue.
Inclusion: Be between 18-85 years of age; Able to give informed consent; ≥6 months post diagnosis of unilateral cortical or sub-cortical stroke; English speaking.
Exclusion: Myocardial infarction in the previous year; History of blood clots in the extremities or any condition in which compression of the thigh or transient ischemia is contraindicated (e.g. wounds in the leg); Chronic pain syndrome; History of head trauma; Comorbid neurological disorder; Peripheral vascular disease; Condition where fatiguing contractions or resisted leg contractions are contraindicated; Low back or hip pain that interferes with lower extremity motor testing; Inability to follow 2 step commands; Resting SBP ≥160 mmHg or DBP ≥ 110 mmHg; Pregnancy or breastfeeding.