Frontlight ResearchEarly access
CompletedPhase 4
Project HOPES: Healthy Options for Pain and Ending Smoking. A Program for Cancer Survivors.
Key facts
- Who runs it
- Duke University
- Where
- Durham, United StatesSee the site
- Trial code
- Status
- Completed
- Phase
- Phase 4
- People taking part
- 21 people enrolled
- Started
- 15 Jul 2024
- Ended
- 29 Aug 2025
- Type of study
- Interventional
- Treatments tested
- Smoking cessation and pain management intervention
- Varenicline
- Record updated
- 25 August 2026
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Can take part
The registry criteria, word for word
Show all 13 criteriaShow less
Who can take part
- Patients with cancer at our targeted recruitment sites
- Have a diagnosis of cancer within the past 5 years (can be currently undergoing treatment)
- Have a life expectancy of at least 1 year
- Report pain within the last 3 weeks of 3 or higher on a 10 point scale
- Have smoked at least 100 cigarettes in their lifetime
- Smoke 5 or more cigarettes per day in the prior 7 days
- Be willing to try to quit smoking
- Not participating in another smoking cessation trial
- Age 18 or older
- Speak English
Who cannot take part
- Hearing impaired
- Deemed too sick to participate
- Evidence of unstable cognitive or mental health problems who cannot properly provide consent
Where in United States
- Duke University Health SystemDurham, United States
About the trial
What the trial wants to find out
The proposed pilot study will develop and test feasibility, acceptability, and signal for efficacy of a smoking cessation and pain management intervention for 20 cancer survivors.
The group in the trial
- Study populationOther group
All patients will receive a smoking cessation and pain management intervention combined with clinician-prescribed varenicline.
Treatment: Smoking cessation and pain management intervention and Varenicline
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Publications
- Pilot study testing varenicline combined with a behavioral intervention for promoting smoking cessation and pain management among patients with cancer.Journal of cancer survivorship : research and practice, 2026
- Record updated
- 25 August 2026