Studies airway germs and infant severe asthma over time
Compares airway germs and blood samples in infants with severe asthma.
Plain-language title generated from the registry record
Registry title: Dynamics of the Upper and Lower Airway Respiratory Microbiomes Associated With Severe Infant Asthma
Key facts
- Where
- Rouen, FranceSee the site
Where in France
- Rouen University HospitalRouen, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital, Rouen
- Trial code
- NCT06044051
- Record updated
- 17 February 2026
- Original description
Nature of potential dysbiosis, interrelation of the different microbiomes of the respiratory tract, and potential role of the immune system in the pathogenesis of severe asthma in infants, and its evolution under treatment.Read full original descriptionShow less
Dynamique Des Microbiomes Respiratoires Des Voies supérieures et inférieures associée à l'Asthme sévère Des Nourrissons
Nature of potential dysbiosis, interrelation of the different microbiomes of the respiratory tract, and potential role of the immune system in the pathogenesis of severe asthma in infants, and its evolution under treatment.
Exploring and understanding these data is to improve patient care and discover new therapeutic targets.
The aim is to open up prospects for therapeutic studies, such as the use of azithromycin as an immunomodulator in infant asthma, the results of which are discordant.
Inclusion: Infants less than 24 months old; Follow-up by a pneumo-pediatrician for severe asthma in infants; Requiring etiological investigations and assessment of severity in day hospitalization, including bronchial fibroscopy (HAS 2009); Parent informed of the research and having signed consent.
Exclusion: Antibiotic therapy in progress or administered the seven days preceding the date of inclusion (day hospitalization); Congenital heart disease with significant left to right shunt; Chronic respiratory disease other than infant asthma (cystic fibrosis, bronchiolitis obliterans); Prematurity <32 WA; Refusal of bronchial fibroscopy.