Studies CFTR gene control in epididymal cells from men with infertility or cystic fibrosis
Uses epididymal samples taken during planned surgery to study the CFTR gene in men.
Plain-language title generated from the registry record
Registry title: Establishment of a Primary Epididymal Cell Model From Epididymal Samples to Study CFTR Gene Regulation
Key facts
- Where
- Brest, FranceSee the site
Where in France
- Antoine VALERIBrest, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital, Brest
- Trial code
- NCT06045702
- Record updated
- 20 March 2026
- Original description
The aim of this observational study is to better understand the role and involvement of the regulatory elements of the CFTR gene, with the aim of better describing the 3D organisation of chromatin at the CFTR locus in epididymal cells in patients with male infertility of any kind, or with cystic fibrosis or bilateral agenesis of the vas deferens, requiring scheduled surgery.Read full original descriptionShow less
Establishment of a Primary Epididymal Cell Model From Epididymal Samples to Study CFTR Gene Regulation
The aim of this observational study is to better understand the role and involvement of the regulatory elements of the CFTR gene, with the aim of better describing the 3D organisation of chromatin at the CFTR locus in epididymal cells in patients with male infertility of any kind, or with cystic fibrosis or bilateral agenesis of the vas deferens, requiring scheduled surgery.
The main questions it aims to answer are:
* to better characterise this 3D organisation of the CFTR locus, the study of regulatory elements in primary epididymal cells is the most relevant and realistic model. * to gain a better understanding of the regulation of the CFTR gene in epididymal cells in order to gain a better understanding of the pathology of male infertility caused by bilateral agenesis of the vas deferens, a symptom and also a borderline form of cystic fibrosis.
Participants will Epididymal samples will be taken by a urologist for the AMP department during the planned surgery. The rest of the samples taken will be recovered for research purposes, with the aim of recovering the epididymal cells contained in the sample. This is in no way an additional procedure and will have no impact on the patient's health..
Inclusion: Male patients over 18 years of age; Patients, without genetic pathology, scheduled for epididymal sampling surgery; Patients with cystic fibrosis or bilateral vas deferens agenesis, scheduled for epididymal sampling surgery; Signature of a consent form.
Exclusion: Patients not scheduled for epididymal harvesting surgery; Patients under legal protection (guardianship, curatorship); Refusal to participate.