Compares two treatments for persistent low-grade cervical lesions linked to HPV
Compares 5-ALA photodynamic therapy with CO2 laser in women with HPV-related cervical lesions.
Plain-language title generated from the registry record
Registry title: Comparison of 5-ALA Photodynamic Therapy and CO2 Laser for Treating Persistent Low-Grade Cervical Lesions With High-Risk HPV Infection
Key facts
- Where
- Wenzhou, ChinaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for women aged 18-65 with a low-grade cervical lesion (LSIL) and a high-risk HPV infection that has lasted more than 1 year.
- Age
- 18 to 65 years, with a history of sexual activity.
- Sex
- Women only.
- Disease stage
- Low-grade squamous intraepithelial lesion (LSIL) of the cervix, confirmed by a cervical biopsy under colposcopy, with an interval of more than 1 year.
- Earlier treatment
- No other drugs related to HPV infection in the past 3 months.
- Biomarker or test result
- Confirmed HR-HPV positive for more than 1 year (same positive type in the typing test).
Main reasons for not taking part
- Total hysterectomy already done
- Endometrial cancer, ovarian cancer or other reproductive tract tumors
- Abnormal heart, liver or kidney function, or immune system disease such as SLE
- Use of immunosuppressants, antiviral agents or glucocorticoids
- Pregnant or breastfeeding women
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT06052033, who can take part
Where in China
- First Affiliated Hospital of Wenzhou Medical UniversityWenzhou, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- First Affiliated Hospital of Wenzhou Medical University
- Trial code
- NCT06052033
- Record updated
- 13 May 2025
- Original description
Non-RCT clinical trial comparing 5-ALA photodynamic therapy and CO2 laser for persistent high-risk HPV-related low-grade cervical lesions.Read full original descriptionShow less
The Effect of 5-aminolaevulinic Acid Photodynamic Therapy Versus C02 Laser in the Treatment of Persistent Cervical Low-grade Squamous Intraepithelial Lesions With High-risk HPV Infection:A Non-randomized Controlled Trail Study
Non-RCT clinical trial comparing 5-ALA photodynamic therapy and CO2 laser for persistent high-risk HPV-related low-grade cervical lesions.
Inclusion: Aged 18-65 years old with a history of sexual activity; Subclinical infected individuals who have been confirmed as HR-HPV positive (if there is the same positive type in the typing test) for more than 1 year using HPV typing test, HPV E6/E7 mRNA test, HPV DNA test, and cervical triple step diagnostic procedure (cytology colposcopy histopathology); Patients diagnosed with LSIL by pathological examination of cervical biopsy under colposcopy with an interval of more than 1 year; No fundamental diseases of important organs; Agree to receive treatment and/or follow-up according to regulations and sign an informed consent form; There has been no history of using other drugs related to HPV infection in the past 3 months.
Exclusion: Concomitant endometrial cancer, ovarian cancer, and other reproductive tract tumors; Using drugs such as immunosuppressants, antiviral agents, and glucocorticoids; HR-HPV persistent infection; Complicated with abnormal heart, liver, and kidney functions, immune dysfunction, or immune system diseases such as systemic lupus erythematosus (SLE); Diabetes patients with uncontrolled blood sugar; A total hysterectomy has been performed; Pregnant and lactating women; Acute reproductive tract inflammation; Patients who do not receive full treatment and follow-up; Those who fail to sign the informed consent form.