L-arginine for Knee Osteoarthritis Patients
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Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 80 years old?
Source: NCT06054633, who can take part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Xiangya Hospital of Central South University
- Trial code
- NCT06054633
- Record updated
- 2 June 2025
- Original description
This study will examine the pain-relief efficacy and safety of L-arginine in knee OA patients.Read full original descriptionShow less
Efficacy and Safety of Oral L-Arginine for Pain Relief in Knee Osteoarthritis: a Randomized, Double-Blind, Placebo-Controlled Trial
This study will examine the pain-relief efficacy and safety of L-arginine in knee OA patients.
Inclusion: Age between 40 and 80 years; Knee OA according to the American College of Rheumatology (ACR) clinical criteria; Knee pain lasting 3 months or longer and a score of 7 or greater on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale (standardized to range from 0-20); Kellgren-Lawrence (KL) grade 2 or 3; Willing to and able to provide written informed consent.
Exclusion: History of injections of corticosteroids in the past three months or hyaluronic acid in the past 6 months in the index knee; History of arthroscopy or open surgery in the index knee in the past 12 months; History of a knee replacement in the index knee or planning to receive such a procedure within 3 months; History of a severe injury in the index knee; Pain in the index knee caused by inflammatory, autoimmune, neoplastic diseases or other diseases; Severe respiratory diseases; History of coronary artery disease and heart failure; Uncontrolled hypertension or diabetes mellitus; Diagnosis of malignant tumors; Abnormal liver or kidney functions, as defined by alanine transaminase or aspartate aminotransferase >two times the upper limit of normal, or blood urea nitrogen or serum creatinine >two times the upper limit of normal; Any use of NSAIDs or other analgesics in the past two weeks; Pregnant or contemplating pregnancy or breast-feeding.