NCT06059313Recruiting
Premorbid Personality Profile of Patients With Cognitive and Behavioral Disorders
Relationship Between Premorbid Personality Traits and Cognitive and Behavioral Disorders
Source: ClinicalTrials.gov · Last updated 29 Jun 2026
Brief summary (registry, in English)
Damages in frontal area present in neurodegenerative disease (frontotemporal degeneration, frontal variant of Alzheimer disease) and in psychiatric disease (bipolar disorder) can affect behavior and cognition including social cognition. Symptoms vary both quantitatively and qualitatively from disease to another and from person to person. It cannot be completely excluded that in some cases, factors of susceptibility such as premorbid personality traits lead to frontal fragility. The study will assess the relationship between premorbid profile using NEO-PI 3 inventory and cognitive and behavioral/psychobehavioral manifestations in patients with behavioral variant of frontotemporal disorder (bvFTD), phenocopy frontotemporal dementia (phFTD), frontal variant of Alzheimer disease, bipolar disorder characterized with frontal damages.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 120 (estimated)
- First submitted
- 22 Sept 2023
- Start date
- 14 Dec 2023
- Primary completion date
- 14 Dec 2026
- Lead sponsor
- Nantes University Hospital
- NCT number
- NCT06059313
What you commit to
- Study type: Observational
- Planned participants: 120
- From 14 Dec 2023 to the primary completion date, 14 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Patient with no caregiver
- Pregnant or breast feeding women
Who the study is looking for
- Patients with behavioral variant of frontotemporal disorder (bvFTD) according to Rascovsky criteria (2011) or patients with phénocopy frontotemporal dementia (phFTD) who fulfill criteria for possible bvFTD and have no imaging abnormalities or patients with frontal variant of Alzheimer disease according to Ossenkopele criteria (2022), or patient with bipolar disorder according to CIM 10 criteria
- Score for Mini-mental state examination ≥ 18
- Patient with caregiver who has who has known him/her in the 10 years preceding the disease onset.
- Patient and caregiver consents (no opposition)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CHU de Nantes Coordinator of this site? Confirm its status | Nantes | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.