Personality traits before illness in people with frontal brain or mood disorders
Compares personality questionnaire results with thinking and behavior changes in adults with frontal-related disorders.
Key facts
- Who runs it
- Nantes University Hospital
- Where
- Nantes, FranceSee the site
- Trial code
- Registry title
- Premorbid Personality Profile of Patients With Cognitive and Behavioral Disorders
- Status
- Recruiting
- People taking part
- 120 people, planned
- Started
- 14 Dec 2023
- Expected to end
- 14 Dec 2026
- Type of study
- Observational, 4 groups
- Treatments tested
- Submission of the NEO-PI-3 questionnaire
- Submission of the Interpersonal Reactivity Index questionnaire (IRI)
- Record updated
- 29 June 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with behavioural variant frontotemporal dementia, phenocopy frontotemporal dementia, frontal variant of Alzheimer disease, or bipolar disorder, who have a caregiver.
- Age
- 18 years and older
- Sex
- All sexes can join.
- Disease stage
- A diagnosis of behavioural variant frontotemporal disorder (Rascovsky criteria 2011), phenocopy frontotemporal dementia (possible bvFTD with no imaging abnormalities), frontal variant of Alzheimer disease (Ossenkopele criteria 2022), or bipolar disorder (CIM 10 criteria). Mini-mental state examination score of 18 or more.
Main reasons for not taking part
- No caregiver
- Caregiver who has not known the patient in the 10 years before the disease began
- Pregnant or breast-feeding women
- Mini-mental state examination score below 18
The registry criteria, word for word
Show all 6 criteriaShow less
Who can take part
- Patients with behavioral variant of frontotemporal disorder (bvFTD) according to Rascovsky criteria (2011) or patients with phénocopy frontotemporal dementia (phFTD) who fulfill criteria for possible bvFTD and have no imaging abnormalities or patients with frontal variant of Alzheimer disease according to Ossenkopele criteria (2022), or patient with bipolar disorder according to CIM 10 criteria
- Score for Mini-mental state examination ≥ 18
- Patient with caregiver who has who has known him/her in the 10 years preceding the disease onset
- Patient and caregiver consents (no opposition)
Who cannot take part
- Patient with no caregiver
- Pregnant or breast feeding women
Where in France
- CHU de NantesNantes, FranceContact: Claire Bretonnière, PHTaking people
About the trial
What the trial wants to find out
Damages in frontal area present in neurodegenerative disease (frontotemporal degeneration, frontal variant of Alzheimer disease) and in psychiatric disease (bipolar disorder) can affect behavior and cognition including social cognition. Symptoms vary both quantitatively and qualitatively from disease to another and from person to person. It cannot be completely excluded that in some cases, factors of susceptibility such as premorbid personality traits lead to frontal fragility.
Read full original descriptionShow less
The study will assess the relationship between premorbid profile using NEO-PI 3 inventory and cognitive and behavioral/psychobehavioral manifestations in patients with behavioral variant of frontotemporal disorder (bvFTD), phenocopy frontotemporal dementia (phFTD), frontal variant of Alzheimer disease, bipolar disorder characterized with frontal damages.
The 4 groups in the trial
- Behavioral variant of frontotemporal disorder (bvFTD)
A group of participants who fulfill Rascovsky criteria (2011) for behavioural variant Frontotemporal Dementia
Treatment: Submission of the NEO-PI-3 questionnaire and Submission of the Interpersonal Reactivity Index questionnaire (IRI)
- Phenocopy frontotemporal dementia (phFTD)
A group of participants who fulfill who fulfill Rascovsky criteria (2011) for possible behavioural variant Frontotemporal Dementia and have no imaging abnormalities.
Treatment: Submission of the NEO-PI-3 questionnaire and Submission of the Interpersonal Reactivity Index questionnaire (IRI)
- Frontal variant of Alzheimer disease
A group of participants who fulfill Ossenkopele criteria (2022)
Treatment: Submission of the NEO-PI-3 questionnaire and Submission of the Interpersonal Reactivity Index questionnaire (IRI)
- Bipolar disorder
A group of participants who fulfill CIM 10 criteria
Treatment: Submission of the NEO-PI-3 questionnaire and Submission of the Interpersonal Reactivity Index questionnaire (IRI)
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Relationship Between Premorbid Personality Traits and Cognitive and Behavioral Disorders
- Plain-language title
- Personality traits before illness in people with frontal brain or mood disordersGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 29 June 2026