Predicting Who Benefits From Interval Exercise After Stroke
Tests high-intensity interval training to see who improves walking after chronic stroke.
Plain-language title generated from the registry record
Registry title: Biomarkers of Reaction To HIIT Exercise
Key facts
- Where
- Decatur, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 89 years old?
Source: NCT06059872, who can take part
Where in United States
- Atlanta VA Medical and Rehab Center, Decatur, GADecatur, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- VA Office of Research and Development
- Trial code
- NCT06059872
- Record updated
- 27 March 2026
- Original description
Stroke survivors with lower limb disability can improve their walking speed with high-intensity interval training (HIIT) rehabilitation therapy. However, some individuals may not respond to HIIT even when fully adherent to the program. To address this, the investigators propose to build a predictive model that identifies if a Veteran with chronic subcortical stroke will improve their walking speed with HIIT by incorporating blood lactate as an early predictor of exercise response, and inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and regional cerebral blood flow (CBF) as predictors of the brain's potential to respond, while also taking into consideration other factors such as comorbidities, demographics, and fitness levels.Read full original descriptionShow less
What Makes a Responder, a Responder? Biomarkers to Help Identify Responders and Resistors to High-intensity Interval Training for Lower Extremity Chronic Stroke
Stroke survivors with lower limb disability can improve their walking speed with high-intensity interval training (HIIT) rehabilitation therapy. However, some individuals may not respond to HIIT even when fully adherent to the program. To address this, the investigators propose to build a predictive model that identifies if a Veteran with chronic subcortical stroke will improve their walking speed with HIIT by incorporating blood lactate as an early predictor of exercise response, and inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and regional cerebral blood flow (CBF) as predictors of the brain's potential to respond, while also taking into consideration other factors such as comorbidities, demographics, and fitness levels.
Inclusion: chronic left or right subcortical stroke as defined by 6 months or more after a cardiovascular accident; lower extremity motor impairment due to stroke that causes a walking speed of less than 0.6 m/s during a 10m walk; Veteran status.
Exclusion: MRI contraindications, including implanted cardiac pacemakers and severe claustrophobia; any neurodegenerative condition other than stroke that may lead to lower extremity impairment; a visual or auditory impairment that may hinder study procedures; any medical condition that would preclude participation in a physical exercise intervention program.