Comparing Two Pacing Methods for Heart Failure With Conduction Delay
Compares two heart pacing methods in adults with heart failure and conduction delay.
Plain-language title generated from the registry record
Registry title: A Randomized Controlled Trial of LOT-CRT Versus conventionaL BiVP in Heart Failure Patients With NICD
Key facts
- Where
- Nanjing, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT06061627, who can take part
Where in China
- The First Affiliated Hospital with Nanjing Medical UniversityNanjing, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- The First Affiliated Hospital with Nanjing Medical University
- Trial code
- NCT06061627
- Record updated
- 14 May 2026
- Original description
BATTLE study has been designed as a prospective, multi-center, randomized, controlled trial. This study will enroll 83 patients with chronic heart failure accompanied by intraventricular block (NICD) over an estimated recruitment period of 3 years. An LOT-CRT group will be compared with a group of conventional BiVP in the follow-up of at least 6 months. The study aimed to compare the curative effect of LOT-CRT in preserving LV systolic function with traditional BiVP in chronic heart failure patients with NICD.Read full original descriptionShow less
A Randomized Controlled Trial of Left Bundle brAnch opTimized Cardiac Resynchronization Therapy Versus conventionaL Bi-vEntricular Pacing in Heart Failure Patients With Nonspecific Intraventricular Conduction Delay
BATTLE study has been designed as a prospective, multi-center, randomized, controlled trial. This study will enroll 83 patients with chronic heart failure accompanied by intraventricular block (NICD) over an estimated recruitment period of 3 years. An LOT-CRT group will be compared with a group of conventional BiVP in the follow-up of at least 6 months. The study aimed to compare the curative effect of LOT-CRT in preserving LV systolic function with traditional BiVP in chronic heart failure patients with NICD.
Inclusion: Ischemic or non ischemic cardiomyopathy; Optimal medical therapy for at lest 3 months; NYHA class II-IV; LVEF≤35% as assessed by echocardiography; Sinus rhythm (may have paroxysmal atrial fibrillation); QRS duration ≥ 150ms; Intraventricular block (NICD), QRS morphology is neither LBBB nor RBBB.
Exclusion: Have a history of acute myocardial infarction within 3 months prior to enrollment; Valvular heart disease that requires or has undergone surgical intervention; After mechanical tricuspid valve replacement; Persistent or permanent atrial fibrillation or atrial flutter; Second or third degree atrioventricular block; Patient's expected survival time is less than 12 months; Pregnant or planned to conceive; Ventricular septal hypertrophy (ventricular septal thickness exceeds 15mm at the end of diastole); Patients with simple and persistent left superior vena cava; Patients with existing pacemaker implantation.