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Comparing two pacemaker placements in patients with fast atrial fibrillation

Compares left bundle branch pacing with right ventricular pacing in adults with fast atrial fibrillation.

Key facts

Who runs it
University Hospital, Rouen
Where
Caen, FranceSee the site
Trial code
Registry title
Benefit of Permanent Stimulation of the Left Branch of the His Bundle Versus Right Ventricular Stimulation After Atrioventricular Node Ablation for Rapid Atrial Fibrillation
Status
Recruiting
People taking part
60 people, planned
Started
27 Nov 2023
Expected to end
27 May 2027
Type of study
Interventional, 2 groups
Treatments tested
  • left bundle branch of His pacing
  • right ventricular pacing
Record updated
10 February 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults who had a pacemaker with a left bundle branch lead and a back-up right ventricular lead. They then had a successful atrioventricular node ablation for rapid atrial fibrillation.

Age
18 years or older
Sex
Men and women can join.
Disease stage
Rapid atrial fibrillation, with a successful atrioventricular node ablation done less than 15 days ago.
Earlier treatment
Must have a pacemaker with a left bundle branch lead and a back-up right ventricular lead. The atrioventricular node ablation must have been done less than 15 days ago.

Main reasons for not taking part

  • Cannot do a maximal cardiorespiratory effort test (VO2 Max test) under good conditions (ADL scale < 5)
  • LVEF < 40% at inclusion
  • Taking part in another interventional trial
  • Deprived of liberty, or under court protection, sub-guardianship or curatorship
  • Pregnant, giving birth, breast-feeding, or without proven contraception

The registry criteria, word for word

Show all 8 criteriaShow less

Who can take part

  • 1/ Pacemaker implanted patient with LBTP lead and back-up right ventricular lead who subsequently underwent successful atrioventricular node ablation for rapid AF 2) NAV ablation procedure performed less than 15 days ago 3) Age ≥ 18 years 4) Woman of childbearing age with effective contraception (estrogen-progestin or intrauterine device or tubal ligation) for at least 1 month and for the duration of the study, and a negative urine pregnancy test by B-HCG at inclusion Or, Postmenopausal woman: confirmatory diagnosis (non-medically induced amenorrhea for at least 12 months prior to the inclusion visit)
  • Membership of a social security scheme 6) Patient follow-up feasible 7) Patient has read and understood the information leaflet and signed the informed consent form

Who cannot take part

  • Impairment of autonomy such that a maximal cardiorespiratory effort test (VO2 Max test) cannot be performed under good conditions (ADL scale < 5)
  • Any history of illness or psychological or sensory abnormality likely to prevent the subject from fully understanding the conditions required for participation in the protocol, or from giving informed consent
  • LVEF < 40% at inclusion
  • Person deprived of liberty by an administrative or judicial decision, or person under court protection, sub-guardianship or curatorship
  • Patient participating in another interventional trial
  • Pregnant, parturient or breast-feeding women, or those without proven contraception

Where in France

  • CHU de CAENCaen, FranceContact: Pierre OLLITRAULT, PrTaking people

About the trial

What the trial wants to find out

The objective of the study is to evaluate the functional benefit of left bundle branch of His pacing compared to right ventricular pacing in patients implanted with a pacemaker prior to a atrioventricular node ablation procedure for rapid atrial fibrillation

The 2 groups in the trial

  • left bundle branch of His pacing (LBTP) then right ventricular pacing (RVP)Treatment being tested

    Treatment: left bundle branch of His pacing and right ventricular pacing

  • right ventricular pacing (RVP) then left bundle branch of His pacing (LBTP)Treatment being tested

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Benefit of Permanent Stimulation of the Left Branch of the His Bundle Versus Right Ventricular Stimulation After Atrioventricular Node Ablation for Rapid Atrial Fibrillation
Plain-language title
Comparing two pacemaker placements in patients with fast atrial fibrillationGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
10 February 2026