NCT06066710RecruitingEarly phase 1
Propranolol in Primary Progressive Aphasia
Trial of Propranolol in Older Adults With Primary Progressive Aphasia
Source: ClinicalTrials.gov · Last updated 17 Jul 2026
Brief summary (registry, in English)
The purpose of this study is to find out how the language of people with Primary Progressive Aphasia is affected by Propranolol. Propranolol is not FDA approved for the treatment of Primary Progressive Aphasia. Propranolol is FDA approved for the treatment of heart conditions such as blood pressure. This research is being done because there are currently no drug treatment options for language impairments and anxiety often experienced by people with Primary Progressive Aphasia.
- Status (registry)
- Recruiting
- Phase (registry)
- Early phase 1
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 8 Sept 2023
- Start date
- 13 Jan 2025
- Primary completion date
- Dec 2026
- Lead sponsor
- University of Missouri-Columbia
- Diseases
- Frontotemporal dementia
- NCT number
- NCT06066710
What you commit to
- Study type: Interventional · Early phase 1
- Planned participants: 30
- From 13 Jan 2025 to the primary completion date, Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- 13\. Drugs that interact with propranolol, such as alpha 2 agonists
- 14\. Claustrophobia, inner ear implants, aneurysm or other surgical clips, metal foreign bodies in eye, pacemaker or other contraindication to MR scanning. Subjects with any implanted device that cannot be verified as MRI compliant will be excluded.
Other illness
- 4\. Major head trauma that contributed to their condition
- 5\. Allergic reaction to adhesives
- 7\. Diabetes
- 8\. Reactive airway disease
Other
- 1\. Unable to provide consent
- 2\. Taking alpha 2 agonists (clonidine and guanfacine)
- 3\. Other major psychological or neurological diagnosis
- 6\. Uncorrected vision/hearing impairments
- 9\. Untreated hypothyroidism
- 10\. Bradyarrhythmia
- 11\. Unexplained syncope
- 12\. Pregnancy (assessed verbally on the days of MR imaging)
Who the study is looking for
- 1\. Age: 50 and older
- 2\. Primary Progressive Aphasia diagnosis
- 3\. Native English speaker
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Missouri - Columbia Coordinator of this site? Confirm its status | Columbia | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.