Studying Muscle and Bone Loss to Understand Frailty in Older Adults
Observes older adults with stroke, brain injury, knee arthritis or breast cancer to study frailty.
Plain-language title generated from the registry record
Registry title: Targeting Osteosarcopaenia and Multimorbidity for Frailty Prevention
Key facts
- Where
- Singapore, SingaporeSee the site
Where in Singapore
- Tan Tock Seng HospitalSingapore, SingaporeTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Tan Tock Seng Hospital
- Trial code
- NCT06073106
- Record updated
- 2 October 2026
- Original description
The aging population and its accompanying burden from non-communicable chronic diseases predicts an increasing impact imposed by frailty on healthcare systems. This is due to a lack of normative data for older adults and reliable risk stratification methods to develop effective approaches to the prevention of frailty.Read full original descriptionShow less
Targeting Osteosarcopaenia and Multimorbidity for Frailty Prevention Through Identification and Deep Phenotyping Methods in Healthy Aging and High-burden Disease Cohorts.
The aging population and its accompanying burden from non-communicable chronic diseases predicts an increasing impact imposed by frailty on healthcare systems. This is due to a lack of normative data for older adults and reliable risk stratification methods to develop effective approaches to the prevention of frailty.
In this study, the investigators plan to form a common dataset for phenotype identification, risk stratification of frailty and its targeted treatment plans in the at-risk and mildly frail population.
Inclusion: Age ≥ 50y; Asian ethnicity; First diagnosis (stroke, Traumatic Brain Injury (TBI), knee osteoarthritis, breast cancer); Living in community; Able to understand 1 step simple commands; For inpatients: (i) within 12 weeks of disease (stroke/TBI) onset, and (ii) within 2 weeks of rehabilitation ward admission; For outpatients: (i) >6 months from initial diagnosis of first stroke, TBI, knee osteoarthritis or breast cancer, and (ii) at least standby assistance, modified independent or independent in ambulation with /without walking.
Exclusion: Previous knee arthroplasty; Impairments affecting understanding of questionnaires and tasks: e.g. severe deafness, severe visual impairment and severe /global aphasia,; Presence of active fractures, dislocations, non-weight bearing status, burns, unhealed wounds, active skin infections/eczema and agitated behaviour or delirium; Presence of tracheostomy, ventilator, renal dialysis, end-organ failure; Patients with disorders of consciousness; Nursing home or dormitory resident; Non-resident status in Singapore (e.g. foreign worker, tourist, temporary visit pass); Anticipated life expectancy < 1 year; Pregnant or lactating participants; For Knee Osteoarthritis patients only:; Alternative diagnosis to knee OA e.g. Referred pain from hip or spine; Other forms of knee arthritis eg. Inflammatory, post traumatic.