Studies how the brain controls breathing in Parkinson's disease
Compares brain control of breathing in people with Parkinson's disease and healthy people.
Plain-language title generated from the registry record
Registry title: Neural Control of Breathing in Parkinson's Disease
Key facts
- Where
- Nijmegen, NetherlandsSee the site
Where in Netherlands
- RadboudumcNijmegen, NetherlandsTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Radboud University Medical Center
- Trial code
- NCT06074614
- Record updated
- 20 December 2024
- Original description
Breathing is a complex process, which can be controlled through voluntary command or neural control. Parkinson's disease (PD) is a progressive neurological disorder. Many individuals with PD experience respiratory problems, such as coughing difficulties or shortness of breath. Changes in neural control of breathing could be part of the reason of these respiratory problems. This study will measure whether neural control of breathing is impaired in individuals with PD compared to healthy individuals.Read full original descriptionShow less
Neural Control of Breathing in Parkinson's Disease: an Exploratory Study
Breathing is a complex process, which can be controlled through voluntary command or neural control. Parkinson's disease (PD) is a progressive neurological disorder. Many individuals with PD experience respiratory problems, such as coughing difficulties or shortness of breath. Changes in neural control of breathing could be part of the reason of these respiratory problems. This study will measure whether neural control of breathing is impaired in individuals with PD compared to healthy individuals.
Inclusion: Healthy subjects: competent adult (>18 years) volunteers; Patients: adult (<18 years) patients with Parkinson's disease, clinically confirmed by a movement disorder specialised neurologist with Hoehn and Yahr staging 1 to 3; Willingness and ability to understand nature and content of the study; Ability to participate and comply with study requirements.
Exclusion: Healthy subjects: previous or ongoing diseases of the central nervous system; Patients: previous or ongoing diseases of the central nervous system, other than Parkinson's disease; History of or current psychiatric treatment; History of or current brain surgery or epilepsy, unclusing deep brain stimulation; Neuromuscular disorders; Pre-existing pulmonary disease, such as chronic obstructive pulmonary disease, asthma or pulmonary fibrosis; TMS incompatibility (metal parts in head or neck, skin allergies); Implanted cardiac pacemaker or defibrillator, neurostimulator, cochlear implant or medical infusion device; Large or ferromagnetic metal parts in the head (exept for a dental wire); Pregnancy; Smoking.