Registry Study of Tiny Blood Vessel Problems After Stroke
Builds a registry tracking tiny brain vessel problems in adults with stroke.
Plain-language title generated from the registry record
Registry title: A Registry Study of Microcirculation Disorder After Cerebral Small Vessel Disease and Ischemic Stroke
Key facts
- Where
- Beijing, ChinaSee the site
Where in China
- Beijing Tiantan HospitalBeijing, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Beijing Tiantan Hospital
- Trial code
- NCT06077305
- Record updated
- 19 October 2023
- Original description
This study aims to construct a registry platform for microcirculatory disorders in a large sample of Chinese patients with cerebral small vessel disease and ischemic stroke; To explore the role of microcirculatory disorders in different types of cerebral small vessel disease and iachemic stroke, as well as their pathogenesis, severity, and prognosis; And to research on the drug treatment of microcirculatory disorders for cerebral small vessel disease and stroke in the real world.Read full original descriptionShow less
A Registry Study of Microcirculation Disorder After Cerebral Small Vessel Disease and Ischemic Stroke, MODEST, Research Protocol
This study aims to construct a registry platform for microcirculatory disorders in a large sample of Chinese patients with cerebral small vessel disease and ischemic stroke; To explore the role of microcirculatory disorders in different types of cerebral small vessel disease and iachemic stroke, as well as their pathogenesis, severity, and prognosis; And to research on the drug treatment of microcirculatory disorders for cerebral small vessel disease and stroke in the real world.
Inclusion: Study 1:; Age ≥ 18 years old; Acute ischemic stroke within 7 days of onset; Sign an informed consent form; Study 2:; Age ≥ 18 years old; Ischemic stroke during recovery period, within 30 days to 1 year of onset; Sign an informed consent form; Study 3:; Age ≥ 18 years old; Within 3 years, there are characteristic lesions of cerebral small vessel disease on head MRI or CT, and they meet at least one of the following criteria:; Paraventricular or deep white matter hyperintensities, Fazekas total score ≥ 2; Paraventricular or deep white matter hyperintensities, Fazekas total score=1, and at least two vascular risk factors (hypertension, hyperlipidemia, diabetes, current smoking, obesity, history of coronary heart disease, history of stroke); Paraventricular or deep white matter hyperintensities, Fazekas total score=1, with ≥ 1 lacune; New recent subcortical small infarcts; Sign an informed consent form.
Exclusion: Cerebral hemorrhage and subarachnoid hemorrhage within 3 months of onset; Confirmed neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Parkinson's syndrome, etc; A mental illness diagnosed according to the DSM-V diagnostic criteria; Cerebral hemorrhage and subarachnoid hemorrhage within 3 months of onset; Confirmed neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Parkinson's syndrome, etc; A mental illness diagnosed according to the DSM-V diagnostic criteria; Cerebral hemorrhage and subarachnoid hemorrhage within 3 months of onset; Confirmed neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Parkinson's syndrome, etc; A mental illness diagnosed according to the DSM-V diagnostic criteria; Study 1:; There are untreated cerebral vascular malformations or untreated aneurysms (diameter>3mm); There are clear diagnoses of non-vascular white matter lesions, such as multiple sclerosis, adult white matter dysplasia, metabolic encephalopathy, etc; Unable to cooperate in completing follow-up visits due to geographical or other reasons; The patient also participated in other clinical trials; Study 2:; There are untreated cerebral vascular malformations or untreated aneurysms (diameter>3mm); There are clear diagnoses of non-vascular white matter lesions, such as multiple sclerosis, adult white matter dysplasia, metabolic encephalopathy, etc; Unable to cooperate in completing follow-up visits due to geographical or other reasons; The patient also participated in other clinical trials; Study 3:; There are untreated cerebral vascular malformations or untreated aneurysms (diameter>3mm); There are clear diagnoses of non-vascular white matter lesions, such as multiple sclerosis, adult white matter dysplasia, metabolic encephalopathy, etc; Unable to cooperate in completing follow-up visits due to geographical or other reasons; The patient also participated in other clinical trials.