Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance
Key facts
- Who runs it
- Copenhagen University Hospital, Rigshospitalet
- Where
- Denmark1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 11 people enrolled
- Started
- 22 Sept 2024
- Ended
- 28 Feb 2025
- Type of study
- Interventional, 2 groupsOne group gets no study treatment, for comparison.
- Treatments tested
- High-intensity exercise training
- Record updated
- 22 June 2025
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 5 criteriaShow less
Who can take part
- Known m.3243A>G mutation in the MT-TL1 gene encoding the mitochondrial leucyl-tRNA 1 gene
- Other known mtDNA point mutations
Who cannot take part
- Use of antiarrhythmic medications or other medications which, in the opinion of the investigators, have the potential to affect outcome measures
- Diagnosed severe heart disease, dysregulated thyroid gland conditions, or other dysregulated endocrinopathies, or other conditions which, in the opinion of the investigators, have the potential to affect outcome measures
- Pregnancy
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
The overarching aim of this intervention study is to interrogate the interconnection between the muscle mitochondrial adaptations and the changes in muscle insulin sensitivity elicited by exercise training in individuals harbouring pathogenic mitochondrial DNA mutations associated with an insulin-resistant phenotype.
Read full original descriptionShow less
In a within-subject parallel-group longitudinal design, participants will undergo an exercise training intervention with one leg, while the contralateral leg will serve as an inactive control. After the exercise intervention, patients will attend an experimental trial including:
* A hyperinsulinemic-euglycemic clamp combined with measurements of femoral artery blood flow and arteriovenous difference of glucose * Muscle biopsy samples
The 2 groups in the trial
- Exercise legTreatment being tested
High-intensity exercise training for one leg
Treatment: High-intensity exercise training
- Control legNo study treatment, for comparison
No exercise training for the controlateral leg
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Exercise-mediated Rescue of Mitochondrial Derangements Driving Insulin Resistance in Humans (EX-MITO-DYS-IR)
- Record updated
- 22 June 2025