Tests an ultrasound brain device for depression that has not improved with treatment
Tests a prototype ultrasound device on the brain in adults with treatment-resistant depression.
Plain-language title generated from the registry record
Registry title: Transcranial Ultrasonic Stimulation in Treatment-resistant Depression : an Open-label Pilot Trial
Key facts
- Where
- Paris, FranceSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT06085950, who can take part
Where in France
- GHU Sainte-AnneParis, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Centre Hospitalier St Anne
- Trial code
- NCT06085950
- Record updated
- 22 June 2026
- Original description
The primary objective of this study is to optimize the protocol for the TUS administration in patients with TRD while gaining an initial impression of treatment efficacy.Read full original descriptionShow less
Transcranial Ultrasonic Stimulation in Treatment-resistant Depression: an Open-label Pilot Trial
The primary objective of this study is to optimize the protocol for the TUS administration in patients with TRD while gaining an initial impression of treatment efficacy.
Inclusion: Age between 18 and 75 years,; Diagnosis of major depressive episode (MDE) as part of major depressive disorder as defined by DSM-5 criteria; Severe MDE (HDRS-17> 20); Drug resistance to at least two well-conducted antidepressant treatment lines; With stable antidepressant treatment for at least 4 weeks before inclusion; Benefiting from a social security scheme; Having given their consent to participate.
Exclusion: Psychiatric history other than a mood disorder; Neurological history, including epilepsy and intracerebral calcifications; History of substance use disorder other than tobacco; Compulsory psychiatric care; Women of childbearing age who do not have a negative pregnancy test and are not using contraception; Contraindication to brain MRI (pacemaker, neurostimulator, injury from metallic shine, …); Protected adults, people under legal safeguard; Pregnant or breastfeeding woman.