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Sleep apnea and thinking skills in people with memory concerns or mild cognitive impairment

Looks at links between sleep apnea and thinking problems in adults with memory concerns.

Key facts

Who runs it
The University of Hong Kong
Where
Hong Kong1 site in 1 countryChoose a country to see its sites
Trial code
Registry title
Sleep Apnea and Cognitive Function in Subjects With Subjective or Mild Cognitive Impairment
Status
Recruiting
People taking part
250 people, planned
Started
7 Mar 2023
Expected to end
31 Mar 2027
Type of study
Observational
Treatments tested
  • Home Sleep Apnea test (HSAT)
Record updated
2 April 2025

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with mild cognitive impairment or subjective cognitive impairment. It studies how sleep apnea, where breathing stops and starts during sleep, relates to memory and thinking.

Age
18 years and above
Sex
All sexes
Disease stage
Mild cognitive impairment by Petersen's criteria, with memory problems but no dementia. Or subjective cognitive impairment: the person feels their thinking is worse, but the Hong Kong Montreal Cognitive Assessment score is normal.

Main reasons for not taking part

  • A diagnosed psychiatric illness, such as major depressive disorder
  • Other clear causes of memory problems, such as old stroke, brain tumour, Parkinson's disease, or alcohol or substance abuse
  • A major unstable illness, or cancer under active treatment
  • Not able to do the Home Sleep Apnea Test
  • Needing a legal guardian, or not able to speak and read Chinese

The registry criteria, word for word

Show all 10 criteriaShow less

Who can take part

  • Aged 18 years and above
  • Clinical diagnosis of mild cognitive impairment (MCI) based on Petersen's criteria. The criteria include the following: (1) memory problems, (2) objective memory disorder, (3) absence of other cognitive disorders or repercussions on daily life, (4) normal general cognitive function and (5) absence of dementia OR,
  • Diagnosis of subjective cognitive impairment, based on the subject's own complaint of cognitive impairment but with an unremarkable assessment of the Hong Kong version of Montreal Cognitive Assessment scores
  • Able to speak and read Chinese
  • Adequate visual and auditory to perform a cognitive test

Who cannot take part

  • Diagnosed psychiatric illness with or without medication, e.g. major depressive disorder
  • Other clear organic causes of cognitive impairment, e.g. old stroke, brain tumour, dementia with Lewy body, Parkinson's disease, normal pressure hydrocephalus, neurosyphilis, autoimmune encephalitis, substance abuse, history of alcohol abuse
  • Diagnosis of major unstable illness or cancer on active treatment
  • Unable to perform Home Sleep Apnea Test
  • Those patients who require legal guardians

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

Obstructive sleep apnea (OSA) is recurrent episodes of partial or complete obstruction of the upper airway during sleep that causes intermittent hypoxia and sleep fragmentation and leads to cardiometabolic and neurocognitive sequelae. Chronic intermittent hypoxia, sleep fragmentation of OSA, and insufficient sleep have been significantly associated with higher risks of neurocognitive impairment, including mild cognitive impairment (MCI) and Alzheimer's disease. Thus, sleep and circadian function might be modifiable neurocognitive impairment factors.

Read full original descriptionShow less

The significance of the study is to understand the relationships of MCI with sleep apnea and sleep-related symptoms, which helps pave the groundwork for further research.

The group in the trial

  • MCI or SCI patient

    At baseline: Cognitive tests, questionnaire, and Home Sleep Apnea Test will be done.

    Treatment: Home Sleep Apnea test (HSAT)

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Exploring the Association of Sleep Apnea With Cognitive Function in Subjects With Subjective or Mild Cognitive Impairment
Plain-language title
Sleep apnea and thinking skills in people with memory concerns or mild cognitive impairmentGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 14 November 2026.
Record updated
2 April 2025