Tests a mild brain stimulation device to help language after stroke
Tests electrical brain stimulation with language exercises in adults with aphasia after stroke.
Plain-language title generated from the registry record
Registry title: tACS to Enhance Language Abilities
Key facts
- Where
- Philadelphia, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 85 years old?
Source: NCT06092814, who can take part
Where in United States
- University of PennsylvaniaPhiladelphia, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Pennsylvania
- Trial code
- NCT06092814
- Record updated
- 24 August 2026
- Original description
The goal of this study is to see if transcranial alternating current stimulation (tACS) can be used to enhance language abilities in people with post-stroke aphasia. Participants will receive real and sham tACS in conjunction with various language tests. Researchers will compare the post-stroke aphasia group with aged matched controls to see if brain response to tACS differs between groups.Read full original descriptionShow less
Transcranial Alternating Current Stimulation (tACS) to Enhance Language Abilities
The goal of this study is to see if transcranial alternating current stimulation (tACS) can be used to enhance language abilities in people with post-stroke aphasia. Participants will receive real and sham tACS in conjunction with various language tests. Researchers will compare the post-stroke aphasia group with aged matched controls to see if brain response to tACS differs between groups.
Inclusion: Presence of aphasia; Suffered a single, left hemisphere stroke; Stroke ≥6 months old (chronic) at the time of enrollment; Right-handedness; Must be able to understand the nature of the study, and give informed consent.
Exclusion: Current abuse of alcohol or drugs, prescription or otherwise; Current abuse of alcohol or drugs, prescription or otherwise; Marked naming impairment; History of significant medical or neurological disorder (other than stroke); History of significant or poorly controlled psychiatric disorders; Diagnosis of a neurodegenerative disease or clinically significant cognitive complaint; Any unrelated neurologic or physical condition that impairs communication ability; History of unrelated neurological conditions including but not limited to traumatic brain injury, stroke, or small vessel disease that has resulted in a neurologic deficit; Any additional neurological condition that would likely reduce the safety of study participation, including central nervous system (CNS) vasculitis, intracranial tumor, intracranial aneurysm, multiple sclerosis or arteriovenous malformations; A medically unstable cardiopulmonary or metabolic disorder; Terminal illness associated with survival <12 months; Major active psychiatric illness that may interfere with required study procedures or treatments as determined by the enrolling physician; Inability to understand the nature of the study; Impaired non-verbal, conceptual processing; Nursing a child, pregnancy, or intent to become pregnant during the study; Clinically significant hearing loss; Contraindications to tACS; Contraindications to MRI; Contraindications to tACS; Contraindications to MRI.