Muscle Recovery After Total Knee Arthroplasty
Key facts
- Who runs it
- Hacettepe University
- Where
- Türkiye1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 20 people enrolled
- Started
- 10 Oct 2024
- Ended
- 11 Sept 2025
- Type of study
- Observational
- Record updated
- 16 March 2026
Who can take part
- Age
- 50 years to 75 years
- Sex
- Women and men
The registry criteria, word for word
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Who can take part
- Age between 50 and 75 years
- Have undergone unilateral total knee arthroplasty surgery due to osteoarthritis
- Hemodynamically stable post-surgery
- Willing to participate in the study
Who cannot take part
- Having undergone revision surgery
- Having a history of cardiovascular surgery
- Having any neurological or oncological issues
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
Total knee arthroplasty (TKA) surgery is a common procedure performed to reduce pain, improve function, and enhance the quality of life in patients with end-stage knee osteoarthritis. As with other knee-related injuries and surgeries, TKA surgery can lead to inhibition of the quadriceps muscle, resulting in a decrease in the muscle's capacity to generate maximum voluntary force. This issue can negatively affect post-injury rehabilitation and function. The long-term persistent neuromuscular muscle inhibition in the quadriceps, one of the most important anti-gravity muscles in our body, leads to muscle atrophy and strength loss, which is more determinant in the development of functional limitations compared to joint range of motion and knee pain.
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There have been no studies found that assess the quadriceps muscle inhibition occurring during the hospitalization of patients undergoing total knee arthroplasty surgery and examine its impact on post-discharge functional status.
The aim of this study is to evaluate the severity of arthrogenic inhibition in the quadriceps muscle of patients following total knee arthroplasty surgery, which is widely practiced in our country and considered the gold standard for the treatment of end-stage knee osteoarthritis. Additionally, the study aims to investigate its impact on post-discharge functional recovery. The data obtained from this study will provide guidance in monitoring patients' early functional recovery post-surgery and in better planning post-surgical rehabilitation.
The study will include patients aged 50-75 who have undergone total knee arthroplasty surgery due to knee osteoarthritis. Demographic information such as age, height, weight, and body mass index will be recorded. Pain will be assessed using a visual analog scale, and edema will be measured during hospitalization, at the 2nd and 6th-week follow-up visits. In addition to all the evaluations, functional status will be assessed at the 2nd and 6th-week follow-up visits using the 5-repetition sit-to-stand test, 10-meter walking test, and 2-minute walking tests, as well as knee function evaluated through the WOMAC and KOS-ADLS questionnaires.
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Invastigation of the Relationship Between Early Quadriceps Arthrogenic Muscle Inhibition and Functional Recovery After Total Knee Arthroplasty
- Record updated
- 16 March 2026