Testing the ORIENT diet in adults over 40 at high risk of stroke

Who can take part

• Patients aged ≥ 40 years
• High risk of stroke (with ≥ 3 of 8 stroke risk factors, including hypertension, dyslipidemia, diabetes, atrial fibrillation or valvular heart disease, smoking history, obvious overweight or obesity, lack of exercise, family history of stroke, or with transient ischemic attack)
• Written informed consent available
• Willingness to complete all assessments and participate in follow-up
• Adequate Visual and auditory acuity to undergo neuropsychological testing

Who cannot take part

• previously diagnosed dementia
• Previous history of major head trauma and any intracranial surgery
• Participation in an ongoing investigational drug study
• Nuts, berries, olive oil, or fish allergies
• Suspected dementia after clinical assessment by study physician at screening visit
• Intracranial abnormalities, such as intracerebral hemorrhage, subarachnoid hemorrhage and other space occupying lesions
• Extrapyramidal symptoms or mental illness which may affect neuropsychological measurement
• Patients presenting a malignant disease with life expectancy < 3 years
• Severe loss of vision, hearing, or communicative ability
• Any MRI contraindications; Exit Criteria:
• Not meet the inclusion criteria
• For any poor adherence, not comply with the requirements of the follow-up, or safety reasons determined by investigator
• Any adverse or serious adverse events during the study period judged by Investigator