Pacing Methods Compared for Heart Failure With Wide QRS
Compares two heart pacing methods in adults with weakened hearts and wide QRS.
Plain-language title generated from the registry record
Registry title: Conduction System Pacing vs Biventricular Pacing in Systolic Dysfunction and Wide QRS: Mortality, Heart Failure Hospitalization or Cardiac Transplant
Key facts
- Where
- Barcelona, SpainSee the site
Where in Spain
- Hospital Clinic de BarcelonaBarcelona, SpainTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Hospital Clinic of Barcelona
- Trial code
- NCT06105580
- Record updated
- 3 April 2026
- Original description
Conduction system pacing vs biventricular resynchronization therapy in systolic dysfunction and wide QRS: mortality, heart failure hospitalization or cardiac transplant (CONSYST-CRT II trial).Read full original descriptionShow less
Conduction System Pacing vs Biventricular Resynchronization Therapy in Systolic Dysfunction and Wide QRS: Mortality, Heart Failure Hospitalization or Cardiac Transplant
Conduction system pacing vs biventricular resynchronization therapy in systolic dysfunction and wide QRS: mortality, heart failure hospitalization or cardiac transplant (CONSYST-CRT II trial).
Superiority trial that aims to study the composite endpoint consisting of all-cause mortality, cardiac transplant or heart failure hospitalization at 12-month follow-up.
Inclusion: Patient must indicate acceptance to participate in the study by signing an informed consent document; Patient must be ≥ 18 years of age; Left bundle branch block, QRS ≥130 and LVEF <=35%. No indication of stimulation for AV block; Non-left bundle branch block, QRS ≥150 and LVEF <=35%; Resynchronization therapy indication for ventricular dysfunction (LVEF <40%) and indication of cardiac pacing for AV block; LVEF <=35% in NYHA class III or IV, atrial fibrillation and intrinsic QRS >=130 ms, provided a strategy to ensure biventricular capture is in place.
Exclusion: Myocardial infarction, unstable angina or cardiac revascularization during the previous 3 months; Pregnancy; Participating currently in a clinical investigation that includes an active treatment.