Frontlight ResearchEarly access
CompletedNo phase
Remimazolam vs. Propofol: Impact on Postoperative Delirium in Neurosurgical Patients
Key facts
- Who runs it
- Samsung Medical Center
- Where
- South Korea1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 696 people enrolled
- Started
- 13 Nov 2023
- Ended
- 21 Feb 2026
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Remimazolam
- Propofol
- Record updated
- 30 June 2026
Who can take part
- Age
- 19 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 6 criteriaShow less
Who can take part
- American Society of Anesthesiologists (ASA) physical status class I - III
Who cannot take part
- Severe respiratory, cardiovascular, or hepatic disease (Child-Pugh C)
- Dependency on psychiatric drugs or alcohol
- Hypersensitivity, allergies, or contraindication to the study drugs
- Severe sensory impairments that impede communication
- Preoperative delirium
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
The investigator aimed to evaluate the incidence of postoperative delirium after remimazolam-based total intravenous anesthesia (TIVA) compared to the propofol-based TIVA in patients undergoing neurosurgery.
The 2 groups in the trial
- RemimazolamTreatment being tested
General anesthesia using continuous infusion of intravenous remimazolam and remifentanil. Remimazolam will be used for maintenance of general anesthesia and adjusted between 0.6-2mg/kg/hr until the end of surgery.
- PropofolExisting treatment, for comparison
General anesthesia using target-controlled infusion of intravenous propofol and remifentanil. Propofol will be adjusted maintaining the BIS between 40-60 until the end of surgery.
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Effect of Remimazolam Versus Propofol Anesthesia on Postoperative Delirium in Neurosurgical Patients: A Randomised, Controlled, Noninferiority Trial
- Publications
- Effect of remimazolam versus propofol anaesthesia on postoperative delirium in neurovascular surgery: a randomised noninferiority trial.British journal of anaesthesia, 2026
- Effect of remimazolam versus propofol anesthesia on postoperative delirium in neurovascular surgery: study protocol for a randomized controlled, non-inferiority trial.Perioperative medicine (London, England), 2024
- Record updated
- 30 June 2026