Screening pregnant women for risk of placental problems in Finland
Checks how well a pre-eclampsia risk calculator predicts placental problems in pregnant women.
Plain-language title generated from the registry record
Registry title: PEPPI Study: Identification of Women at Risk for Placental Dysfunction
Key facts
- Where
- Oulu, FinlandSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for pregnant women in their first trimester who understand Finnish. It also includes the child's biological father and the baby born from the pregnancy.
- Age
- Mothers and fathers must be 18 years or older. Children are included if born to a mother in the study.
- Sex
- All sexes are listed in the record. Mothers are pregnant women and fathers are the biological fathers.
- Biomarker or test result
- Mothers need blood samples taken in the first trimester. One sub-study also needs blood samples in the third trimester and from the umbilical cord at birth.
Main reasons for not taking part
- Multiple pregnancy
- Miscarriage or termination of this pregnancy
- No first trimester blood sample
- Does not understand Finnish (fathers)
- No consent from parents (children)
Read by machine on 12 November 2026.
Where in Finland
- The Wellbeing Services County of North OstrobothniaOulu, FinlandContact: Jaana E Nevalainen, Assoc ProfTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Oulu University Hospital
- Trial code
- NCT06115122
- Record updated
- 5 August 2025
- Original description
The main purpose of this study is to evaluate Fetal Medicine Foundation's pre-eclampsia risk calculator using maternal characteristics, first trimester serum placental growth factor (PlGF) and mean arterial pressure (MAP) in a Finnish general population.Read full original descriptionShow less
PEPPI Study: Identification of Women at Risk for Placental Dysfunction During the First and Third Trimesters of Pregnancy
The main purpose of this study is to evaluate Fetal Medicine Foundation's pre-eclampsia risk calculator using maternal characteristics, first trimester serum placental growth factor (PlGF) and mean arterial pressure (MAP) in a Finnish general population.
Condition or disease: pre-eclampsia, intrauterine growth restriction, polycystic ovary syndrome
Inclusion: Pregnant (first trimester); Understands Finnish; ≥18 years; Signed informed consent; Participates in PEPPI-study (criteria above); Blood samples at first and third trimester of pregnancy; Permits blood sampling from the umbilical cord when the baby is born; Biological father to the child born for the mother who participated in PEPPI study; ≥18 years; Signed informed consent; Born to mother who participated in PEPPI study; Signed informed consent from parent(s); Signed informed consent from parent(s); Mother has blood samples taken at first and third trimester (iron status); Child has blood samples taken at birth and at 3 months of age.
Exclusion: Multiple pregnancy; Miscarriage/termination of the index pregnancy; No first trimester blood sampling; No first or third trimester blood sampling; No umbilical cord blood sample after baby is born; Fathers; Does not understand Finnish; Children; No consent from parent(s); Mother/father declines participation; No consent from parent(s); No blood samples from mother; No blood samples from child.
Mothers.