Studies how stroke may affect thinking skills over time in adults
Follows stroke patients with brain scans and memory tests 2 years apart.
Plain-language title generated from the registry record
Registry title: StrokeCog-BBB to Study Cognitive Outcomes Following Stroke
Key facts
- Where
- Palo Alto, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 45 and 90 years old?
Source: NCT06116630, who can take part
Where in United States
- Stanford University HospitalPalo Alto, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Stanford University
- Trial code
- NCT06116630
- Record updated
- 18 April 2024
- Original description
The goal of this observational study is to learn about cognitive outcomes in stroke patients. The main question it aims to answer are: 1. Is blood-brain barrier permeability compromised for years after stroke, 2. Is a blood biomarker of imbalanced angiogenesis dysregulated in chronic stroke and 3. Are there biomarkers that separately or together predicts cognitive decline after stroke, and are other MRI, blood, and clinical characteristics that are associated. Participants will undergo cognitive testing and MRIs two years apart. Researchers will compare cognitive outcomes in non-stroke patients who have cardiovascular risk factors to understand the effects of stroke on these outcomes.Read full original descriptionShow less
StrokeCog-BBB to Study Cognitive Outcomes Following Stroke
The goal of this observational study is to learn about cognitive outcomes in stroke patients. The main question it aims to answer are: 1. Is blood-brain barrier permeability compromised for years after stroke, 2. Is a blood biomarker of imbalanced angiogenesis dysregulated in chronic stroke and 3. Are there biomarkers that separately or together predicts cognitive decline after stroke, and are other MRI, blood, and clinical characteristics that are associated. Participants will undergo cognitive testing and MRIs two years apart. Researchers will compare cognitive outcomes in non-stroke patients who have cardiovascular risk factors to understand the effects of stroke on these outcomes.
Inclusion: Aged 45 years or over; One or more vascular risk factors (e.g. high blood pressure, diabetes or vascular disease such as angina, a previous heart attack, a heart bypass or peripheral artery disease in the legs); Established vascular disease (previous MI, angina, vascular stent in the peripheral bed); Sufficiently fluent in written and spoken English; Living independently in the community; Willing/able to give consent to study participation.
Exclusion: Current treatment with IL-1 blockade or established immune-suppressant therapy (e.g. IL-1Ra or IL-1 antibodies), or treatment within the last 3 months; No history of any previous ischaemic or haemorrhagic stroke, a mini-stroke or a serious brain injury; Major neurological disease (immune mediated, previous brain tumors); Do not have dementia; Renovascular Disease; Currently participating in a clinical trial of investigation medicinal product (CTIMP) or device trial.