Esophageal pressure-guided ventilator settings for obese patients with severe lung failure
Tests a personalized ventilator setting method in adults with obesity and ARDS.
Plain-language title generated from the registry record
Registry title: Transpulmonary Pressure - Guided Mechanical Ventilation in Morbidly Obese ARDS Patients: a Feasibility Study.
Key facts
- Where
- Angers, Le Kremlin-Bicêtre, Lyon, Paris, and Poitiers, FranceSee the 5 sites
Where in France
- CHU AngersAngers, FranceTaking people
- Hôpital Bicêtre AP-HPLe Kremlin-Bicêtre, FranceTaking people
- Hôpital de la Croix-Rousse, HCLLyon, FranceTaking people
- AP-HP Hopital Europeen Georges PompidouParis, FranceTaking people
- CHU la MiletriePoitiers, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Assistance Publique - Hôpitaux de Paris
- Trial code
- NCT06119516
- Record updated
- 21 April 2026
- Original description
The goal of this clinical trial is to test a personalized intervention aiming to optimize the mechanical ventilator settings in morbidly obese patients suffering from moderate to severe Acute Respiratory Distress Syndrome (ARDS). The intervention consists of personalized measurements and calculations of the different pressures inside the thorax. The main question to answer is:Read full original descriptionShow less
Transpulmonary Pressure - Guided Mechanical Ventilation in Morbidly Obese ARDS Patients: a Feasibility Study.
The goal of this clinical trial is to test a personalized intervention aiming to optimize the mechanical ventilator settings in morbidly obese patients suffering from moderate to severe Acute Respiratory Distress Syndrome (ARDS). The intervention consists of personalized measurements and calculations of the different pressures inside the thorax. The main question to answer is:
• Will the evaluated esophageal pressure-guided strategy lead to different mechanical ventilator settings than suggested by a strategy largely used in ARDS patients in France?
A specific nasogastric probe permitting to measure esophageal pressure will monitor participants. Esophageal pressure will act as an indicator of the pleural pressure. Other respiratory signals displayed by the mechanical ventilators will also be acquired.
Further, ventilator settings will be adjusted to the evaluated esophageal pressure-guided strategy, with possible benefit of this personalized approach.
Inclusion: Adult patient (aged 18 years or older); Class III morbid obesity (BMI > 40 kg/m2); Moderate or severe ARDS criteria (according to the Berlin definition); Less than 72 hours between fulfilling moderate or severe ARDS criteria and inclusion; Tracheal intubation and invasive mechanical ventilation; Informed consent (patient, next of kin), with possibility of an emergency procedure with deferred consent; Covid-19 and non-Covid-19 patients.
Exclusion: Order to limit life-sustaining therapy; Contra-indication to nasogastric tube (uncontrolled coagulopathy, severe thrombocytopenia, nasal trauma, esophageal varices); ExtraCorporal Membrane Oxygenation (ECMO) in use; Invasive mechanical ventilation > 96 hours; Elevated intracranial pressure; Active air-leak: pneumothorax, pneumomediastinum; Pregnancy or breast feeding; Patient on state medical aid.