Tests a blood test for detecting lung cancer early in high-risk adults
Studies a blood test for early lung cancer detection in high-risk adults getting routine scans.
Plain-language title generated from the registry record
Registry title: Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening
Key facts
- Where
- Baltimore, Binghamton, Charleston, Chicago, Deerfield, DeLand, Doral, DuBois, Florence, Gainesville, Grand Forks, Gulfport, Houston, Hyannis, Jackson, Kissimmee, Lancaster, Leawood, Los Angeles, Milwaukee, Mullica Hill, Oklahoma City, Philadelphia, Pierre, Port Orange, Portland, Raleigh, Reno, Sayre, Springfield, Stamford, The Villages, Tyler, Wichita, Winter Park, and Wyomissing, United StatesSee the 36 sites
Where in United States
- Ascension St. Agnes HospitalBaltimore, United StatesTaking people
- Our Lady of Lourdes HospitalBinghamton, United StatesTaking people
- Medical University of South Carolina (MUSC)Charleston, United StatesTaking people
- University of ChicagoChicago, United StatesTaking people
- WalgreensDeerfield, United StatesTaking people
- Hillcrest Medical ResearchDeLand, United StatesTaking people
- Universal Axon Clinical ResearchDoral, United StatesTaking people
- Clinical Research Associates of Central PADuBois, United StatesTaking people
- McLeod HealthFlorence, United StatesTaking people
- SpeciCare, IncGainesville, United StatesTaking people
- Altru Health SystemGrand Forks, United StatesTaking people
- Memorial Hospital at GulfportGulfport, United StatesTaking people
- Horizon Clinical Research GroupHouston, United StatesTaking people
- Cape Cod HospitalHyannis, United StatesTaking people
- The Jackson Clinic, PAJackson, United StatesTaking people
- I.H.S Health, LLCKissimmee, United StatesTaking people
- US Digestive Health at LancasterLancaster, United StatesTaking people
- Aton HealthLeawood, United StatesTaking people
- Science 37Los Angeles, United StatesTaking people
- Ascension Columbia St. Mary's WisconsinMilwaukee, United StatesTaking people
- Inspira Medical CenterMullica Hill, United StatesTaking people
- Hightower ClinicalOklahoma City, United StatesTaking people
- Temple UniversityPhiladelphia, United StatesTaking people
- Circle Clinical ResearchPierre, United StatesTaking people
- United Medical ResearchPort Orange, United StatesTaking people
- Oregon Health Science UniversityPortland, United StatesTaking people
- WakemedRaleigh, United StatesTaking people
- Renown Regional Medical CenterReno, United StatesTaking people
- Guthrie Medical GroupSayre, United StatesTaking people
- Springfield Clinic, LLPSpringfield, United StatesTaking people
- Stamford HospitalStamford, United StatesTaking people
- Charter ResearchThe Villages, United StatesTaking people
- CHRISTUS Trinity Mother Frances Health SystemTyler, United StatesTaking people
- Ascension Via Christi WichitaWichita, United StatesTaking people
- Charter ResearchWinter Park, United StatesTaking people
- US Digestive Health at WyomissingWyomissing, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Freenome Holdings Inc.
- Trial code
- NCT06122077
- Record updated
- 5 August 2025
- Original description
The PROACT LUNG study is a prospective multi-center observational study to validate a blood-based test for the early detection of lung cancer by collecting blood samples from high-risk participants who will undergo a routine, standard-of-care screening Low-Dose Computed Tomography (LDCT).Read full original descriptionShow less
The PROACT LUNG Study: A Prospective, Observational,Clinical Validation Study of the Freenome Multiomics Blood Test for Lung Cancer Screening (FRNM-007)
The PROACT LUNG study is a prospective multi-center observational study to validate a blood-based test for the early detection of lung cancer by collecting blood samples from high-risk participants who will undergo a routine, standard-of-care screening Low-Dose Computed Tomography (LDCT).
Inclusion: Age 50 years or older within 30 days of enrollment; Current or former smokers with a cumulative smoking history of ≥ 20 pack-year; Able to comprehend and willing to sign and date the informed consent and HIPAA authorization documents.
Exclusion: History of any malignancy within prior 5 years of enrollment (except for non- melanoma skin cancer); Screened for lung cancer or having chest CT scan 12 months before enrollment; Received a blood transfusion in the 30 days preceding enrollment; Participated or currently participating in a clinical research study in which an experimental medication has been administered during the 60 days preceding enrollment; Any active therapy for cancer, including but not limited to surgery, chemotherapy, biologic therapy, immunotherapy, and/or radiation therapy at the time of enrollment; History of organ, tissue, and bone marrow transplantation; Having signs and symptoms of lung cancer such as hemoptysis, superior vena cava syndrome, Cushing syndrome, and Pancoast syndrome; Any condition that in the opinion of the Investigator should not be enrolled in the study; Known to be pregnant; Participated or currently participating in another Freenome-sponsored clinical study.