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Taking peoplePhase 3

Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty

Key facts

Who runs it
University Health Network, Toronto
Where
Canada3 sites in 1 countryChoose a country to see its sites
Trial code
Status
Recruiting
Phase
Phase 3
People taking part
3,216 people, planned
Started
16 Apr 2024
Expected to end
31 Dec 2030
Type of study
Interventional, 2 groupsOne group gets a placebo (a dummy treatment), for comparison.
Treatments tested
  • Vitamin C
  • Placebo
Record updated
13 November 2026

Who can take part

Age
18 years and older
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 10 criteriaShow less

Who can take part

  • Patients >18 years old
  • Undergoing a unilateral or simultaneous bilateral primary total knee arthroplasty for advanced osteoarthritis of the knee

Who cannot take part

  • TKA for infection (septic joint), fracture, ankylosing spondylitis, lupus, or psoriatic arthritis
  • History of kidney stones, acute or chronic renal failure, hemochromatosis, or glucose-6-phosphate deficiency
  • Unlikely to comply with follow-up (e.g., no fixed address, plans to move out of town)
  • Language difficulties that would impede valid completion of questionnaires
  • Planned staged bilateral TKA
  • Treating surgeon deems patient inappropriate for inclusion in trial
  • Unwilling to abstain from non-study vitamin C during trial except for up to 100 mg/day contained in a routinely used multivitamin
  • Pregnant or planning to become pregnant during the study

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

Phase III Multicentre, parallel-group, blinded, 1:1 randomized controlled trial to determine the effect of perioperative vitamin C supplementation on reducing the prevalence of persistent pain 3 months after total knee arthroplasty.

The 2 groups in the trial

  • InterventionTreatment being tested

    Preoperative Vitamin C capsules

    Treatment: Vitamin C

  • PlaceboPlacebo, for comparison

    Preoperative placebo capsules

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
PeRiOperative VItamin C to Reduce perSistent paIn After tOtal kNee Arthroplasty (PROVISION): a Multicentre Randomized Controlled Trial
Record updated
13 November 2026