The Effects of Anesthetics on Brain Network Connectivity in Patients With Supratentorial Glioma
Key facts
- Who runs it
- Beijing Tiantan Hospital
- Where
- China1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Recruiting
- People taking part
- 120 people, planned
- Started
- 31 Aug 2023
- Planned end
- 31 Dec 2025
- Type of study
- Observational, 3 groups
- Treatments tested
- Dexmedetomidine
- Propofol
- Remimazolam Injection
- Record updated
- 14 February 2025
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 13 criteriaShow less
Who can take part
- Diagnosed as unilateral supratentorial glioma by MRI
- Selective operation
- Age over 18 years old
- ASA I-II
- Right handedness
Who cannot take part
- Drug and/or alcohol abuse
- History of cerebrovascular disease, brain trauma, chemotherapy and radiotherapy, or psychotropic drugs
- History of intracranial surgery
- History of dementia or mental illness
- Severe bradycardia (heart rate less than 40 beats per minute), sick sinus syndrome or second-to-third degree atrioventricular block
- Pregnant or lactating women
- Contraindications for MRI
- Severe hepatic or renal dysfunction
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
Perioperative anesthesia can affect postoperative cognitive function. In our previous study, intraoperative dexmedetomidine (Dex) infusion reduced the incidence of delirium within the first 5 days after brain tumor. However, the mechanism is still unclear. With the development of neuroimaging, multimodal neuroimaging technology provide a new method to explore the underlying mechanism. Therefore, the purpose of this study is to analyze the alterations of brain network under sedation and anesthesia by different anesthetics in patients with supratentorial glioma and their association with cognition.
The 3 groups in the trial
- Dex group
Participants will be sedated and maintained by dexmedetomidine.
Treatment: Dexmedetomidine
- Propofol group
Participants will be sedated and maintained by propofol.
Treatment: Propofol
- Remimazolam group
Participants will be sedated and maintained by remimazolam.
Treatment: Remimazolam Injection
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- The Alterations of Brain Network Connectivity Under Sedation and Anesthesia in Patients With Supratentorial Glioma
- Record updated
- 14 February 2025