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Testing a Score to Predict Where Seizures Start in the Brain

Checks whether a new 5-point score predicts seizure origin using stereo-electroencephalography in people with epilepsy.

Plain-language title generated from the registry record
Registry title: 5-SENSE Score Validation Study

Key facts

Where
Freiburg im Breisgau, GermanySee the site

Where in Germany

  • Epilepsy Centre, University Hospital FreiburgFreiburg im Breisgau, GermanyNo longer taking part

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Trial details

Who runs it
Duke University
Trial code
NCT06138808
Record updated
5 June 2026
Original description
The purpose of this study is to assess how well a new scoring system called the 5-SENSE score can predict where seizures start in the brain using Stereoelectroencephalography (SEEG). The 5-SENSE Score is a 5-point score based on routine presurgical work-up, designed to assist in predicting whether SEEG can identify a focal seizure onset zone, thereby sparing patients the risk of undergoing this invasive diagnostic procedure.Read full original descriptionShow less

Prognostic Value of the 5-SENSE Score to Predict Focality of the Seizure-onset Zone as Assessed by Stereo-electroencephalography - a Prospective Multicenter Validation Study

The purpose of this study is to assess how well a new scoring system called the 5-SENSE score can predict where seizures start in the brain using Stereoelectroencephalography (SEEG). The 5-SENSE Score is a 5-point score based on routine presurgical work-up, designed to assist in predicting whether SEEG can identify a focal seizure onset zone, thereby sparing patients the risk of undergoing this invasive diagnostic procedure.

Inclusion: patients aged 15 years or older in whom no direct surgical approach can be offered and who are discussed in the multidisciplinary team discussion; availability of complete non-invasive presurgical work-up (including high-resolution MRI according to the in-center epilepsy protocol, video-telemetry with the recording of a minimum of one habitual clinic and EEG seizure, available as original files for review).

Exclusion: no telemetry/scalp EEG in center; no protocol MRI in center; subdural/GRID electrodes.

ClinicalTrials.gov NCT06138808