Testing a Score to Predict Where Seizures Start in the Brain
Checks whether a new 5-point score predicts seizure origin using stereo-electroencephalography in people with epilepsy.
Plain-language title generated from the registry record
Registry title: 5-SENSE Score Validation Study
Key facts
- Where
- Chicago, Durham, Gainesville, and Pittsburgh, United StatesSee the 4 sites
Where in United States
- Northwestern UniversityChicago, United StatesNo longer taking part
- Duke University Health SystemDurham, United StatesNo longer taking part
- University of Florida College of MedicineGainesville, United StatesNo longer taking part
- Presbyterian-Shadyside HospitalPittsburgh, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Duke University
- Trial code
- NCT06138808
- Record updated
- 5 June 2026
- Original description
The purpose of this study is to assess how well a new scoring system called the 5-SENSE score can predict where seizures start in the brain using Stereoelectroencephalography (SEEG). The 5-SENSE Score is a 5-point score based on routine presurgical work-up, designed to assist in predicting whether SEEG can identify a focal seizure onset zone, thereby sparing patients the risk of undergoing this invasive diagnostic procedure.Read full original descriptionShow less
Prognostic Value of the 5-SENSE Score to Predict Focality of the Seizure-onset Zone as Assessed by Stereo-electroencephalography - a Prospective Multicenter Validation Study
The purpose of this study is to assess how well a new scoring system called the 5-SENSE score can predict where seizures start in the brain using Stereoelectroencephalography (SEEG). The 5-SENSE Score is a 5-point score based on routine presurgical work-up, designed to assist in predicting whether SEEG can identify a focal seizure onset zone, thereby sparing patients the risk of undergoing this invasive diagnostic procedure.
Inclusion: patients aged 15 years or older in whom no direct surgical approach can be offered and who are discussed in the multidisciplinary team discussion; availability of complete non-invasive presurgical work-up (including high-resolution MRI according to the in-center epilepsy protocol, video-telemetry with the recording of a minimum of one habitual clinic and EEG seizure, available as original files for review).
Exclusion: no telemetry/scalp EEG in center; no protocol MRI in center; subdural/GRID electrodes.