Tests several new medicines for long-term weight control in adults with obesity
Tests several investigational medicines for weight control in adults with obesity or overweight.
Plain-language title generated from the registry record
Registry title: A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight
Key facts
- Where
- Buenos Aires and Rosario, ArgentinaSee the 7 sites
- Phase
- Phase 2
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT06143956, who can take part
Where in Argentina
- CARDIAMET Investigaciones MédicasBuenos Aires, ArgentinaNot yet recruiting
- Centro de Investigaciones Metabólicas (CINME)Buenos Aires, ArgentinaTaking people
- Centro Medico Dra. Laura Maffei- Investigacion Clinica AplicadaBuenos Aires, ArgentinaTaking people
- Centro Médico ViamonteBuenos Aires, ArgentinaTaking people
- Cicemo SrlBuenos Aires, ArgentinaTaking people
- Mautalen Salud e InvestigaciónBuenos Aires, ArgentinaNot yet recruiting
- Instituto Médico Catamarca IMECRosario, ArgentinaNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Eli Lilly and Company
- Trial code
- NCT06143956
- Record updated
- 7 October 2026
- Original description
The purpose of this Phase-2 chronic weight management master protocol (CWMM) is to create a framework to evaluate the safety and efficacy of various investigational interventions for chronic weight management with intervention-specific appendices (ISAs). The CWMM establishes entry criteria for newly enrolled participants across the master and the ISAs. The ISAs may start independently of other ISAs as interventions become available for clinical testing. The results for the CWMM screening record will be reported when all the ISA's complete.Read full original descriptionShow less
A Master Protocol for a Randomized, Controlled, Clinical Trial of Multiple Interventions for Chronic Weight Management in Adult Participants With Obesity or Overweight
The purpose of this Phase-2 chronic weight management master protocol (CWMM) is to create a framework to evaluate the safety and efficacy of various investigational interventions for chronic weight management with intervention-specific appendices (ISAs). The CWMM establishes entry criteria for newly enrolled participants across the master and the ISAs. The ISAs may start independently of other ISAs as interventions become available for clinical testing. The results for the CWMM screening record will be reported when all the ISA's complete.
Inclusion: Have a body mass index (BMI); ≥30 kilogram/square meter (kg/m²), or; ≥27 kg/m² and <30 kg/m², or with at least 1 weight-related comorbidity; Have had a stable body weight for the 3 months prior to randomization (<5%) body weight gain and/or loss.
Exclusion: Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed >1 year prior to screening; Have any of the following cardiovascular conditions within 3 months prior to screening:; acute myocardial infarction; cerebrovascular accident (stroke); unstable angina, or; hospitalization due to congestive heart failure; Have type 1 diabetes mellitus, latent autoimmune diabetes in adults, or history of ketoacidosis or hyperosmolar coma; Have poorly controlled hypertension; Have signs and symptoms of any liver disease other than nonalcoholic fatty liver disease; Have a history of symptomatic gallbladder disease within the past 2 years; Have a lifetime history of suicide attempts.