Studies immune patterns in the lungs and blood of people with lung disease
Compares immune patterns in airway samples and blood from adults with asthma or COPD.
Plain-language title generated from the registry record
Registry title: Study of Inflammatory and Physiological Profiles of Healthy and Diseased Lung
Key facts
- Where
- London, United KingdomSee the site
Where in United Kingdom
- Guy's & St Thomas' NHS Foundation TrustLondon, United KingdomTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Guy's and St Thomas' NHS Foundation Trust
- Trial code
- NCT06144476
- Record updated
- 4 June 2026
- Original description
There are over 700,000 UK hospital admissions every year with lung disease symptoms. Two of the most common lung diseases contributing to these numbers are asthma and chronic obstructive pulmonary disease (COPD). The immunopathology of these diseases is not fully understood. Matched samples from the respiratory tract and circulation will be used to identify immune patterns throughout the respiratory system to elucidate the immunopathology of airway disease.Read full original descriptionShow less
Study of Inflammatory and Physiological Profiles of Healthy and Diseased Lung
There are over 700,000 UK hospital admissions every year with lung disease symptoms. Two of the most common lung diseases contributing to these numbers are asthma and chronic obstructive pulmonary disease (COPD). The immunopathology of these diseases is not fully understood. Matched samples from the respiratory tract and circulation will be used to identify immune patterns throughout the respiratory system to elucidate the immunopathology of airway disease.
Inclusion: Participant is willing and able to give informed consent for participation in the study; Aged 18 years or above; Patient: known or suspected airway disease; Healthy volunteer: considered to be in good health with no significant comorbidity (immune disorder, cancer etc.).
Exclusion: Surgery within the preceding 6 weeks; Alcohol or recreational drug abuse; Known or suspected current pulmonary tuberculosis, HIV (human immunodeficiency virus), Hepatitis B Virus, Hepatitis C Virus; History of psychiatric, medical, or surgical disorders that in the opinion of the chief investigator may interfere with sample collection, undergo a bronchoscopy, or may compromise study completion or data collection; Participants who are pregnant; Diagnosis of immunodeficiency requiring treatment; Unable to provide written informed consent; Unable to read or write English; Be considered, in the opinion of the investigator, to be an unsuitable candidate for the study.