Genetic germ test to guide treatment of severe infections in adults with AIDS
Checks whether a genetic germ test guides treatment of severe pneumonia or sepsis in AIDS.
Plain-language title generated from the registry record
Registry title: Metagenomic Next-Generation Sequencing Guides Anti-Infection Strategies
Key facts
- Where
- Guangzhou, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT06145841, who can take part
Where in China
- Linghua LiGuangzhou, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Guangzhou 8th People's Hospital
- Trial code
- NCT06145841
- Record updated
- 24 November 2023
- Original description
This study aims to observe the effectiveness of clinical application in guiding anti-infection treatments in AIDS patients with severe pneumonia and/or sepsis using Metagenomic Next-Generation Sequencing-based technology in the real worldRead full original descriptionShow less
Clinical Application of Metagenomic Next-Generation Sequencing-Guided Anti-Infection Strategies in AIDS Patients With Severe Pneumonia and/or Sepsis
This study aims to observe the effectiveness of clinical application in guiding anti-infection treatments in AIDS patients with severe pneumonia and/or sepsis using Metagenomic Next-Generation Sequencing-based technology in the real world
Inclusion: Confirmed HIV infection; Progression to AIDS stage: CD4+ count <200 cells/ul and/or occurrence of AIDS opportunistic infections; Age between 18 and 65 years; Meeting the diagnosis of severe pneumonia or septic shock:; The criteria for severe pneumonia diagnosis refer to the 2021 ATS (American Thoracic Society) and IDSA (Infectious Diseases Society of America) guidelines for the treatment of community-acquired pneumonia; The criteria for septic shock refer to the Chinese Society of Critical Care Medicine's "Chinese Guidelines for the Emergency Treatment of Sepsis/Septic Shock (2018).
Exclusion: Concurrent AIDS-related or unrelated tumors; Alcohol abuse or drug use; Coexisting central nervous system lesions, severe liver disease, or cirrhosis; Severe underlying diseases of the heart, lungs, liver, kidneys, etc; The researcher believes that the overall condition of the subject affects the evaluation and completion of the trial; Women who are pregnant or breastfeeding.