Tests a whole-procedure approach to catheter ablation for atrial fibrillation
Studies a full-procedure catheter treatment for atrial fibrillation in adults with irregular heartbeat.
Plain-language title generated from the registry record
Registry title: Application Value of Whole-procedure Optimization for Catheter Ablation of Atrial Fibrillation
Key facts
- Where
- Zhengzhou, ChinaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with atrial fibrillation (AF) who are having catheter ablation with radiofrequency for the first time.
- Age
- 18 to 80 years
- Sex
- All sexes can join.
- Disease stage
- Atrial fibrillation recorded on an ECG. The record mentions paroxysmal and persistent AF treatment plans.
- Earlier treatment
- This must be the first radiofrequency catheter ablation. People with a previous AF radiofrequency ablation or CABG cannot join.
- Biomarker or test result
- AF rhythm recorded by ECG.
Main reasons for not taking part
- Blood clot (thrombosis) in the left atrium
- Left ventricular ejection fraction below 35%
- Abnormal thyroid function
- Previous AF radiofrequency ablation or CABG
- Left atrium diameter above 65 mm or volume above 200 ml
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT06145906, who can take part
Where in China
- Department of Cardiology, Henan Provincial People's HospitalZhengzhou, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Henan Provincial People's Hospital
- Trial code
- NCT06145906
- Record updated
- 18 March 2024
- Original description
The success rate of single-procedure atrial arrhythmia-free survival particularly ranged from 40% to 66% in persistent AF ablation. However, The surgical Cox maze III procedure has been established to be an effective curative strategy for AF with an AF-free survival rate of more than 95%. The main reason is the difficulty of creating continuous, transmural, and durable lesions by catheter ablation, especially when the procedure is performed on some complex anatomical structures in which epicardial muscular bundles may serve as components of the reentrant circuits.Read full original descriptionShow less
Application Value of Whole-procedure Optimization for Catheter Ablation of Atrial Fibrillation
The success rate of single-procedure atrial arrhythmia-free survival particularly ranged from 40% to 66% in persistent AF ablation. However, The surgical Cox maze III procedure has been established to be an effective curative strategy for AF with an AF-free survival rate of more than 95%. The main reason is the difficulty of creating continuous, transmural, and durable lesions by catheter ablation, especially when the procedure is performed on some complex anatomical structures in which epicardial muscular bundles may serve as components of the reentrant circuits.
The durability of the conduction block is a crucial factor for long-term effective AF ablation since previous studies reported that the reconnected Pulmonary veins contributed to the atrial tachycardia recurrence after persistent AF ablation. In addition, it is possible that the inadequate lesions accidentally produce new arrhythmogenic substrates. Therefore, new and better techniques are always chosen to minimize the reconnection of Pulmonary vein isolation (PVI) and additional ablation.
For paroxysmal AF, the ablation strategy of PVI plus superior vena cava isolation is chosen while PVI, superior vena cava isolation, and linear ablation of linear ablations of the mitral isthmus, roofline and posterior wall line of the left atrium, and cavotricuspid isthmus (CTI) for persistent AF. Any symptomatic or asymptomatic atrial arrhythmia lasting more than 30 seconds was regarded as an AF recurrence after a 3-month blanking period. The primary outcome was defined as 12-month atrial arrhythmia-free survival. The secondary outcomes include the block rate of PVI, superior vena cava isolation, and all linear ablations.
Inclusion: Radiofrequency catheter ablation for the first time; AF rhythm recorded by ECG.
Exclusion: Previous history of AF radiofrequency ablation and CABG; Thrombosis in left atrium; Left ventricular ejection fraction of < 35%; Abnormal thyroid function; Left atrium diameter of > 65 mm or the volume of > 200 ml.