Tests cardiac rehabilitation in adults with Fontan failure, a heart condition
Compares an exercise rehabilitation program with usual care in adults with Fontan failure.
Plain-language title generated from the registry record
Registry title: REHAB Fontan Failure: A Trial of Cardiac Rehabilitation
Key facts
- Where
- Nashville and Stanford, United StatesSee the 2 sites
Where in United States
- Vanderbilt University Medical CenterNashville, United StatesTaking people
- Stanford UniversityStanford, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Stanford University
- Trial code
- NCT06150950
- Record updated
- 5 January 2026
- Original description
The goal of this clinical trial is to compare the impact of cardiac rehabilitation on Fontan failure patients' exertional tolerance, frailty, and quality of life.Read full original descriptionShow less
RCT of the Effects of Cardiac reHABilitation (REHAB) Among Patients With Fontan Failure
The goal of this clinical trial is to compare the impact of cardiac rehabilitation on Fontan failure patients' exertional tolerance, frailty, and quality of life.
1. Among patients with Fontan failure, will cardiac rehabilitation increase average daily steps compared to usual care? 2. Among patients with Fontan failure, will cardiac rehabilitation improve exertional tolerance (as measured by cardiopulmonary exercise testing), frailty, and self-reported quality of life metrics compared to usual care?
Inclusion: Fontan failure, defined as history of a Fontan procedure and at least one of the following: systemic ventricular EF <50% (by echocardiography, cardiac magnetic resonance imaging, or computer tomography), protein losing enteropathy, plastic bronchitis, chronic loop diuretics prescribed by ACHD Cardiologist, and/or peak VO2 < 50% predicted (by FRIEND equation); Age >= 18 years old.
Exclusion: Recent (<3 months) planned Fontan pathway percutaneous or surgical intervention; Symptomatic, uncontrolled arrhythmias; Contraindication to cardiac rehab or already enrolled in cardiac rehabilitation; Inotrope-dependence; Pregnancy; Inability to comply with the protocol; Resting hypoxemia with baseline oxygen saturation <80%.