Exercise and rehabilitation program tested for fatigue after COVID-19
Tests an exercise and rehabilitation program for fatigue in adults with long COVID.
Plain-language title generated from the registry record
Registry title: Pursuing Reduction in Fatigue After COVID-19 Via Exercise and Rehabilitation (PREFACER): A Randomized Feasibility Trial
Key facts
- Where
- London, CanadaSee the site
Where in Canada
- Parkwood Hospital - St. Joseph's Health Care LondonLondon, CanadaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Lawson Research Institute of St. Joseph's
- Trial code
- NCT06156176
- Record updated
- 1 August 2025
- Original description
Long COVID is a complex condition that affects approximately 1.4 million Canadians following SARS-CoV-2 infection. Fatigue is the most common symptom of Long COVID. This feasibility trial will evaluate a new rehabilitation program called COVIDEx for treating fatigue after COVID-19, and compare its effectiveness to the standard treatment currently used. The experimental treatment group will receive an 8-week multi-modal rehabilitation program with two 50-minute sessions per week. 60 participants will be recruited, randomly assigned to the COVIDEx program or standard of care (SoC) and followed for 24 weeks.Read full original descriptionShow less
Pursuing Reduction in Fatigue After COVID-19 Via Exercise and Rehabilitation (PREFACER): A Randomized Feasibility Trial
Long COVID is a complex condition that affects approximately 1.4 million Canadians following SARS-CoV-2 infection. Fatigue is the most common symptom of Long COVID. This feasibility trial will evaluate a new rehabilitation program called COVIDEx for treating fatigue after COVID-19, and compare its effectiveness to the standard treatment currently used. The experimental treatment group will receive an 8-week multi-modal rehabilitation program with two 50-minute sessions per week. 60 participants will be recruited, randomly assigned to the COVIDEx program or standard of care (SoC) and followed for 24 weeks.
Inclusion: Adults of at least 18 years of age; Able to provide informed consent; Can speak and understand English; Documented history of SARS-CoV-2 infection (positive PCR/antigen test during acute illness or clinical diagnosis by physician during or after the acute illness); Fatigue symptoms within 3 months of COVID-19 infection, lasting at least 2 months; Fatigue symptoms cannot be explained by an alternative diagnosis; Fatigue symptoms may be new onset following initial recovery from an acute COVID-19 infection or persist from the initial illness; Fatigue symptoms may have an episodic nature, fluctuate or relapse over time; Minimal functional capability: able to walk 10-15 minutes and be recovered within 30-60 minutes or without significant post-exertional malaise (PEM); Has applicable technology to access Microsoft Teams and Webex (i.e., computer, laptop, tablet).
Exclusion: Received investigational agents as part of a separate study within 30 days of the screening visit; Active SARS-CoV-2 infection; Pre-existing physical, cognitive, and/or mental health conditions that make exercise contraindicated, consent unattainable, or that cause symptoms similar to those seen in post COVID-19 (e.g., major neurocognitive disorder, schizophrenia, chronic fatigue syndrome) that could affect data; Has any type of metal bodily implant in head or heart (i.e., pins, plates, pacemakers); Current participation in other studies related to COVID-19, exercise, and/or fatigue interventions OR participation within 30 days of the screening visit; Inability to follow study procedures; Pregnant and/or breastfeeding.