Under construction – not a live service
Sign in
Taking peopleNo phase

Mechanically or Kinematically Aligned Total Knee Prosthesis

Key facts

Who runs it
Clinique du Sport, Bordeaux Mérignac
Where
France1 site in 1 countryChoose a country to see its sites
Trial code
Status
Recruiting
People taking part
120 people, planned
Started
5 Oct 2023
Expected to end
30 Sept 2027
Type of study
Interventional, 2 groupsOne group gets an existing treatment, for comparison.
Treatments tested
  • kinematic knee prosthesis
  • biomechanic knee prosthesis
Record updated
6 April 2026

Who can take part

Age
18 years and older
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 9 criteriaShow less

Who can take part

  • Patient followed as part of a consultation 1 year after TKA placement
  • Adult patient
  • Patient affiliated to a social security system
  • Patient informed of the study and formally included (signing of informed consent) before the first research review

Who cannot take part

  • Patient with another condition (acquired pathology) of the lower limbs (e.g. severe osteoarthritis of the contralateral knee or hip/ankle) and/or of the nervous system (e.g. Parkinson's) which may significantly affect the quality of walking
  • Patient with a contralateral knee prosthesis
  • Pregnant patient
  • Patient deprived of liberty by judicial or administrative decision,
  • Adult patient subject to a legal protection measure or unable to express consent

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

The mechanical alignment technique (Mechanical Alignment - MA) of a total knee prosthesis (TKA) was developed with the aim of making the installation of a TKA simple and reproducible, and that the prosthetic biomechanics are acceptable, thus promoting good longevity of implants. This is a technique that does not aim to restore the constitutional anatomy of the knee; bone cuts are systematically made at fixed angles, in the 3 planes of space, in relation to the mechanical axes of the long bones (femur and tibia). This non-personalized implantation technique therefore systematically alters the anatomy, laxity and kinematics of the knee, causing up to 50% of residual symptoms after prosthetic implantation and 20% of dissatisfied patients.

Read full original descriptionShow less

In order to improve the clinical results of TKA, a new, more personalized and physiological technique was developed in 2007, called Kinematic Alignment (KA). This technique aims to restore the pre-arthritic anatomy, unique to each knee. Patients with severe constitutional deformity of the lower limb therefore retain this deformity after kinematic prosthetic replacement. The impact of the alignment technique on the biomechanics of the prosthetic knee remains poorly described. The main objective of this study is therefore to compare knee biomechanics between mechanical TKA and kinematic TKA.

The 2 groups in the trial

  • patients with kinematic aligned knee prosthesisTreatment being tested

    Treatment: kinematic knee prosthesis

  • patients with biomechanic aligned knee prosthesisExisting treatment, for comparison

    Treatment: biomechanic knee prosthesis

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Mechanically or Kinematically Aligned Total Knee Prosthesis: Prospective and Comparative Study of Clinical, Stereoradiographic, and Biomechanical Results
Record updated
6 April 2026