Compares two procedures for long-lasting irregular heartbeat in adults
Compares a combined heart-surface procedure with standard catheter ablation in adults.
Key facts
- Who runs it
- Barts & The London NHS Trust
- Where
- London, United KingdomSee the site
- Trial code
- Registry title
- Convergent Ablation Plus Left Atrial Appendage Isolation for the Treatment of Persistent Atrial Fibrillation
- Status
- Recruiting
- People taking part
- 48 people, planned
- Started
- 2 Aug 2024
- Expected to end
- Nov 2026
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Epicardial AF ablation using AtriCure EPi-Sense-AF Guided Coagulation System with Left Atrial Appendage Exclusion using the AtriCure LARIAT Suture Delivery Device.
- Standard Endocardial Catheter Ablation
- Record updated
- 25 June 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with long-standing persistent atrial fibrillation (an irregular heartbeat). It compares a combined heart ablation with the LARIAT procedure against standard catheter ablation.
- Age
- Older than 18 and younger than 80 years.
- Sex
- All sexes can join.
- Disease stage
- Persistent atrial fibrillation lasting more than 1 year. The left atrium must be smaller than 6cm (2.4 in).
- Earlier treatment
- People who had earlier catheter or surgical ablation, heart surgery or abdominal surgery cannot join.
Main reasons for not taking part
- Atrial fibrillation with a reversible cause, or temporary atrial fibrillation
- No left atrial appendage, or one that was closed off by surgery before
- Cannot take anticoagulant (blood-thinning) medicines
- Hypertrophic cardiomyopathy or significant valve disease
- Taking part in another investigational study
The registry criteria, word for word
Show all 12 criteriaShow less
Who can take part
- Age > 18 years; < 80 years
- Persistent AF > 1-year duration
- Left atrium size < 6cm
- Pts should be able to provide written informed consent
Who cannot take part
- Subject is absent of LAA or if the LAA is previously surgically ligated
- Subject has had previous cardiac surgery or abdominal surgery
- Subject has had previous catheter or surgical ablation
- Patients with significant valve disease
- Subjects currently enrolled in another investigational study except in case of observational registry with no associated treatments
- Subject has a reversible cause of AF or transient AF
- Subject has contraindication to anticoagulation
- Patients with hypertrophic cardiomyopathy
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Where in United Kingdom
- St. Bartholomew's HospitalLondon, United KingdomContact: Syed AhsanTaking people
About the trial
What the trial wants to find out
A randomised controlled clinical trial to assess efficacy of convergent ablation with the LARIAT procedure, as compared to standard endocardial catheter ablation in patients with long-standing persistent atrial fibrillation (AF).
The 2 groups in the trial
- Convergent AF Ablation with Left Atrial Appendage ExclusionTreatment being tested
Two Staged Convergent AF Ablation Procedure Stage 1 - Minimally Invasive Surgical Epicardial Ablation Procedure with concomitant LAA exclusion (LARIAT procedure) Stage 2 - Percutaneous Endocardial Catheter Ablation
Treatment: Epicardial AF ablation using AtriCure EPi-Sense-AF Guided Coagulation System with Left Atrial Appendage Exclusion using the AtriCure LARIAT Suture Delivery Device. and Standard Endocardial Catheter Ablation
- Standard Endocardial Catheter AblationExisting treatment, for comparison
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Convergent Ablation Plus Left Atrial Appendage Isolation for the Treatment of Persistent Atrial Fibrillation
- Plain-language title
- Compares two procedures for long-lasting irregular heartbeat in adultsGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT06165510, who can take part
- Record updated
- 25 June 2026