Under construction – not a live service
Sign in
Taking people in SwedenNo phase

Tests exercise training in people with lupus

Tests high-intensity interval and resistance training in adults with systemic lupus erythematosus.

Key facts

Who runs it
Karolinska Institutet
Where
Stockholm, SwedenSee the site
Trial code
Registry title
Effects of High-intensity Interval Training in Patients With Systemic Lupus Erythematosus
Status
Recruiting
People taking part
40 people, planned
Started
1 Nov 2022
Expected to end
31 Dec 2026
Type of study
Interventional, 2 groupsOne group gets no study treatment, for comparison.
Treatments tested
  • HIIT combined with resistance training
Record updated
12 December 2023

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with systemic lupus erythematosus (SLE) who have low to moderate disease activity and little or no organ damage. It tests high-intensity interval training combined with resistance training.

Age
18 years or older
Sex
All sexes can join.
Disease stage
Low to moderate disease activity (for example a SLEDAI-2K score of 5 or less) and low, minimal or no organ damage (for example a SLICC/ACR DI score of 3 or less).
Earlier treatment
Medicine treatment must be stable. People who do regular aerobic fitness and muscle strength training at fixed times more than 1 time a week cannot join.

Main reasons for not taking part

  • Signs of cerebro-vascular disease, pulmonary embolus, pulmonary hypertension, pulmonary fibrosis or cardiovascular disease within one year before entry
  • Angina pectoris, myocardial infarction, dyspnea at rest, uncontrolled blood pressure or uncontrolled diabetes within one year before entry
  • Cannot do a maximal exercise cycle test because of the disease or health risks
  • Other conditions that strongly reduce the ability to exercise
  • Pregnancy

The registry criteria, word for word

Show all 13 criteriaShow less

Who can take part

  • ≥18 years old
  • Fulfilment of the 1982 American College of Rheumatology (ACR) criteria; or 2012 Systemic Lupus International Collaborating Clinics (SLICC/ACR-Damage Index (DI)) classification criteria; or EULAR/ACR criteria; or patients that have received the diagnosis SLE on clinical grounds
  • Low to moderate disease activity, for example defined as a score of ≤5 in the clinical version of the SLE Disease Activity Index 2000 (SLEDAI-2K), i.e., excluding the serological descriptors (anti-dsDNA positivity and low complement levels)
  • Low/minimal or no organ damage, for example defined as a score of ≤3 in the SLICC/ACR DI
  • Stable pharmacological treatment
  • The ability to perform a maximal ergometercycle exercise test
  • Be able to read and understand Swedish

Who cannot take part

  • Symptoms or signs of cerebro-vascular disease, pulmonary embolus, pulmonary hypertension, pulmonary fibrosis, cardiovascular disease, angina pectoris, myocardial infarction, dyspnea at rest, uncontrolled blood pressure and uncontrolled diabetes within one year prior to study entry. Chronic kidney disease with
  • Patients who fulfil the absolute contraindications for maximal exercise testing according to American Heart Association
  • Patients who cannot perform a maximal ergometercycle exercise test due to the disease
  • Diseases or other conditions that strongly reduce the ability to exercise or that exercise is not recommended
  • Patients who perform regular aerobic fitness training and muscle strength exercise sessions at fixed times, >1 time/week
  • Pregnancy

Where in Sweden

  • Carina BoströmStockholm, SwedenContact: Carina M Boström, DrTaking people

About the trial

What the trial wants to find out

The aim of this study is to evaluate the safety and effects of high-intensity interval training (HIIT) combined with resistance training in patients with systemic lupus erythematosus

The 2 groups in the trial

  • High-intensity interval training (HIIT) combined with resistance trainingTreatment being tested

    Patients with SLE will undergo supervised HIIT on an ergometercycle 4 x 4 minutes interval (85-90% of maximal heart rate in 4 minutes and lower intensity for another 4 minutes etc). The HIIT is combined with resistance exercises for upper and lower extremity. In total the supervised training takes around 50 minutes per occasion and will be performed 2 times/week, for 3 months. In addition, the patients will exercise, according to the program, by themselves once a week. Between months 3 and 6 the patients exercise by themselves, 3 times/week, with video-call/telephone support from a physiotherapist once a week.

    Treatment: HIIT combined with resistance training

  • Control groupNo study treatment, for comparison

    Both the control group and the HIIT combined with resistance training group receive standard care.

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Effects of High-intensity Interval Training Combined With Resistance Training in Patients With Systemic Lupus Erythematosus
Plain-language title
Tests exercise training in people with lupusGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
12 December 2023