Single Bladder Chemotherapy Dose After Kidney Tumor Treatment in Upper Urinary Tract Cancer
Tests one bladder dose of chemotherapy versus saline in adults with upper tract urothelial carcinoma.
Plain-language title generated from the registry record
Registry title: POST URS Chemotherapy Instillation
Key facts
- Where
- Ashdod, Be’er Ya‘aqov, Beersheba, Haifa, Petah Tikva, Rehovot, Safed, and Tel Aviv, IsraelSee the 10 sites
Where in Israel
- Assuta Ashdod HospitalAshdod, IsraelTaking people
- Shamir Medical CenterBe’er Ya‘aqov, IsraelTaking people
- Soroka University Medical CenterBeersheba, IsraelTaking people
- Bnai Zion Medical CenterHaifa, IsraelTaking people
- Carmel Medical CenterHaifa, IsraelTaking people
- Rambam Health Care CampusHaifa, IsraelTaking people
- Rabin Medical Center - Beilinson and HasharonPetah Tikva, IsraelTaking people
- Kaplan Medical CenterRehovot, IsraelTaking people
- Ziv Medical CenterSafed, IsraelTaking people
- Tel Aviv Sourasky Medical Center IchilovTel Aviv, IsraelTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Carmel Medical Center
- Trial code
- NCT06167057
- Record updated
- 20 December 2023
- Original description
The goal of this study is to evaluate the safety and oncological outcomes of single chemotherapy bladder instillation following endoscopic treatment for UTUC in UTUC suspected patients .The main aim is to determine the efficacy of a single, post URS, chemotherapy bladder instillation to reduce IVR.Read full original descriptionShow less
Single Bladder Instillation With Chemotherapy Following Endoscopic Treatment for Upper Tract Urothelial Carcinoma to Reduce Bladder Recurrence
The goal of this study is to evaluate the safety and oncological outcomes of single chemotherapy bladder instillation following endoscopic treatment for UTUC in UTUC suspected patients .The main aim is to determine the efficacy of a single, post URS, chemotherapy bladder instillation to reduce IVR.
Participants will be given single chemotherapy bladder instillation within 24h following ureteroscopy and will follow routine follow-up for IVR which will include white light cystoscopy ;patients with suspected IVR (based on either imaging or cystoscopy) will undergo TURBT.
Inclusion: Radiographic and/or cytological suspicion for UTUC; Planned endoscopic procedure for treatment / diagnosis of UTUC; Patients with bladder cancer history are eligible if meeting both following criteria:; No recurrence within the last two years Are not on active bladder irrigation protocol; Patients with history of UTUC are eligible if last endoscopic treatment or RNU was >1 year prior to enrollment; Age ≥ 18 years; Performance status ECOG 0-2.
Exclusion: Subjects who have had bladder / prostate radiotherapy; Subjects with bladder cancer history on active bladder irrigation protocols or with active disease within two years prior to enrollment; Subjects with previously treated UTUC within one year prior to enrollment; Subjects with metastatic disease.