Scan-guided blood thinner plan after heart valve replacement in people with severe aortic stenosis
Tests CT-guided blood thinner use versus aspirin alone in people after TAVI.
Plain-language title generated from the registry record
Registry title: Personalized, CT-guided Antithrombotic Therapy Versus Lifelong Single Antiplatelet Therapy to Reduce Thromboembolic and Bleeding Events in Non-atrial Fibrillation Patients After Transcatheter Aortic Valve Implantation
Key facts
- Where
- Besançon, Bordeaux, Brest, Clermont-Ferrand, Lille, Massy, Neuilly-Sur-Seine, Paris, Rennes, Saint-Denis, Saint-Herblain, Strasbourg Cedex, and Toulouse Cedex 3, FranceSee the 14 sites
- Phase
- Phase 4
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 110 years old?
Source: NCT06168370, who can take part
Where in France
- CHU BesançonBesançon, FranceTaking people
- Centre hospitalier Universitaire de BordeauxBordeaux, FranceTaking people
- Centre Hospitalier Régional et Universitaire de BrestBrest, FranceTaking people
- University Hospital Of Clermont-FerrandClermont-Ferrand, FranceTaking people
- Centre Hospitalier Universitaire de LilleLille, FranceTaking people
- Hôpital Privé Jacques CartierMassy, FranceTaking people
- Centre Medico Chirurgical Ambroise Pare HartmannNeuilly-Sur-Seine, FranceTaking people
- APHP BichatParis, FranceTaking people
- Hôpital de la Pitié-SalpêtrièreParis, FranceTaking people
- Centre Hospitalier Universitaire de RennesRennes, FranceTaking people
- Societe D'Exploitation Du Centre Cardiologique Du NordSaint-Denis, FranceTaking people
- Centre Hospitalier Universitaire de NantesSaint-Herblain, FranceTaking people
- Les Hopitaux Universitaires De StrasbourgStrasbourg Cedex, FranceTaking people
- Clinique PasteurToulouse Cedex 3, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- St. Antonius Hospital
- Trial code
- NCT06168370EU 2023-504637-42-01
- Record updated
- 19 May 2026
- Original description
The POPular ATLANTIS trial aims to investigate CT-guided antithrombotic therapy compared to lifelong single antiplatelet therapy after a transcatheter aortic valve implantation (TAVI) procedure. Only patients without an indication for anticoagulants will be included in this trial. Currently, lifelong single antiplatelet therapy (mostly aspirin) is considered the standard of care for these patients. However, this approach poses a bleeding risk with only a minimal reduction in thromboembolic events.Read full original descriptionShow less
Personalized, CT-guided Antithrombotic Therapy Versus Lifelong Single Antiplatelet Therapy to Reduce Thromboembolic and Bleeding Events in Non-atrial Fibrillation Patients After Transcatheter Aortic Valve Implantation: a Pragmatic, International, Multicentre, Randomized Clinical Trial
The POPular ATLANTIS trial aims to investigate CT-guided antithrombotic therapy compared to lifelong single antiplatelet therapy after a transcatheter aortic valve implantation (TAVI) procedure. Only patients without an indication for anticoagulants will be included in this trial. Currently, lifelong single antiplatelet therapy (mostly aspirin) is considered the standard of care for these patients. However, this approach poses a bleeding risk with only a minimal reduction in thromboembolic events.
After 3 months, a CT scan will be conducted to assess the presence of thrombosis on the newly implanted TAVI valve. Based on the results of a 4D CT scan, the decision will be made whether the patient should receive no anticoagulant or antithrombotic therapy with apixaban. CT-guided antithrombotic therapy holds the potential for a greater reduction in thromboembolic events without increasing the bleeding risk.
Inclusion: Successful TAVI (according to the VARC-3 criteria)10 with any approved device; Ability to understand and to comply with the study protocol; Written informed consent.
Exclusion: Existing indication for oral anticoagulation (e.g. atrial fibrillation, obstructive valve thrombosis detected by echocardiography prior to inclusion); Existing indication for dual antiplatelet therapy at three months after TAVI (rare at this time point); Creatinine clearance <15 mL/min (based on the CKD-EPI formula) or on renal replacement therapy.