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Taking people in BrazilEarly phase 1

Testing beetroot extract for hard-to-control high blood pressure

Tests beetroot extract against a placebo in adults with resistant high blood pressure.

Plain-language title generated from the registry record
Registry title: Effect of Nitrate Supplementation on Blood Pressure and Microvascular Function of Resistant Hypertensive Patients

Key facts

Where
Rio de Janeiro, BrazilSee the site
Phase
Early phase 1

AI summary: who the study is looking for

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults aged 18 to 75 with resistant hypertension (high blood pressure that stays high despite medicines). It tests a beetroot supplement against a placebo.

Age
18 to 75 years
Sex
All sexes can join.
Disease stage
Resistant hypertension, with the diagnosis written in the medical record.
Earlier treatment
No change of medicines and no higher doses in the last 30 days.

Main reasons for not taking part

  • Neoplasms (tumours)
  • Heart failure
  • Use of medicines that contain nitrate
  • Renal denervation (a kidney nerve procedure)

Read by machine on 9 November 2026.

Could this be for you?

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 75 years old?

Source: NCT06169241, who can take part

Where in Brazil

  • National Institute of CardiologyRio de Janeiro, BrazilTaking people

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Trial details

Who runs it
National Institute of Cardiology, Laranjeiras, Brazil
Trial code
NCT06169241
Record updated
13 April 2026
Original description
Arterial hypertension (AH) has been identified as an important public health problem and considered a new epidemic with high mortality and morbidity. High blood pressure (BP) levels increase the chances of coronary artery disease (CAD), heart failure (HF), stroke, chronic renal failure (CRF) and death. Beetroot powder may be an easier way to increase the availability of nitric oxide and consequently vasodilation in these patients. However, studies are needed to evaluate its benefits in patients with AH.Read full original descriptionShow less

Effect of Nitrate Supplementation on Blood Pressure and Systemic Microvascular Function of Resistant Hypertensive Patients

Arterial hypertension (AH) has been identified as an important public health problem and considered a new epidemic with high mortality and morbidity. High blood pressure (BP) levels increase the chances of coronary artery disease (CAD), heart failure (HF), stroke, chronic renal failure (CRF) and death. Beetroot powder may be an easier way to increase the availability of nitric oxide and consequently vasodilation in these patients. However, studies are needed to evaluate its benefits in patients with AH.

Inclusion: Resistant hypertension, with a diagnosis described in the medical record, without changing medications or increasing doses in the last 30 days.

Exclusion: use of medications with nitrate in their formula; heart failure; neoplasms; patients undergoing renal denervation.

ClinicalTrials.gov NCT06169241