Comparing two bypass graft types in women having heart surgery
Compares two blood vessel grafts used to bypass blocked heart arteries in women.
Plain-language title generated from the registry record
Registry title: One-year Patency Comparison Between Radial Artery and No-touch Saphenous Vein Grafts in Women Undergoing Isolated CABG
Key facts
- Where
- São Paulo, BrazilSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT06179329, who can take part
Where in Brazil
- Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina de São PauloSão Paulo, BrazilTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Sao Paulo General Hospital
- Trial code
- NCT06179329
- Record updated
- 12 December 2025
- Original description
The use of a graft from the left internal thoracic artery to the left anterior descending artery has become the gold standard for the indication of coronary artery bypass grafting. However, choosing a graft for the second-best coronary artery, focusing on long-term patency, is still a challenge. The saphenous vein using the "no-touch" technique is an alternative to a radial artery graft, but there is little evidence, especially in women. This randomized clinical study aims to compare the patency of these grafts in the second-best coronary artery in women undergoing coronary artery bypass grafting.Read full original descriptionShow less
No-Touch Saphenous Venous Harvesting TechniQue versUs Radial artEry in Coronary Artery Bypass Grafting in womEN: The QUEEN Multicenter Randomized Controlled Trial
The use of a graft from the left internal thoracic artery to the left anterior descending artery has become the gold standard for the indication of coronary artery bypass grafting. However, choosing a graft for the second-best coronary artery, focusing on long-term patency, is still a challenge. The saphenous vein using the "no-touch" technique is an alternative to a radial artery graft, but there is little evidence, especially in women. This randomized clinical study aims to compare the patency of these grafts in the second-best coronary artery in women undergoing coronary artery bypass grafting.
Inclusion: Women aged 18 years or older and younger than 75 years, undergoing isolated and primary myocardial revascularization surgery, with triarterial coronary artery disease (three vessels involved) in vessels subject to surgical revascularization and left ventricular ejection fraction greater than 35%. The target coronary vessels of the study will be those in the territory of the left circumflex artery and the right coronary artery, which must have at least 1.5 mm in diameter, and with proximal obstructive lesions of at least 70%.
Exclusion: Inability to use the saphenous and/or radial vein; Positive Allen test using a pulse oximeter; Presence of abnormal flow detected by means of a Doppler exam in one of the grafts to be used; History of vasculitis or Raynaud's syndrome, varicose veins, or history of previous saphenous vein removal; Conditions that may affect patient follow-up; Presence of advanced peripheral arterial disease; Known contrast allergy: Presence of a documented allergy to the contrast agent used in radiological procedures; Impossibility of tracking due to geographic inaccessibility; Patients with lack of adherence to guidelines and/or prescribed medications; Preoperative conditions:; Lack of the patient's written informed consent; Presence of poorly controlled diabetes, with a glycated hemoglobin value >8 mg/dl; Emergency or salvage surgery, where the intervention needs to be performed quickly due to the critical clinical condition of the patient; Renal failure with glomerular filtration rate (creatinine clearance) <30 mL/min.