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Taking people in IcelandNo phase

MicroRNAs as Biomarkers for Obstructive Sleep Apnea

Key facts

Who runs it
University of Pennsylvania
Where
Reykjavik, IcelandSee the siteAlso in 1 other country, 2 sites
Trial code
Status
Recruiting
People taking part
500 people, planned
Started
1 Apr 2024
Expected to end
30 Apr 2028
Type of study
Observational, 2 groups
Treatments tested
  • Positive Airway Pressure
Record updated
3 August 2026

Who can take part

Age
18 years to 75 years
Sex
Women and men

The registry criteria, word for word

Show all 21 criteriaShow less

Who can take part

  • age 18-75 years
  • moderate-severe OSA (defined as AHI ≥15 events/hour)
  • willing to accept PAP therapy
  • age 18-75 years
  • no OSA (defined as AHI <5 events/hour)

Who cannot take part

  • home oxygen therapy
  • recent changes (within 3 months) to BP medications among those who are on these medications
  • organ transplantation
  • home oxygen therapy
  • organ transplantation
  • clinical history of chronic kidney disease (Stage 5) requiring dialysis, or renal transplant
  • clinical history of chronic kidney disease (Stage 5) requiring dialysis, or renal transplant
  • current use of PAP or other OSA treatments
  • presence of Cheyne-Stokes Respiration (CSR) in sleep study
  • predominantly central sleep apnea (AHI≥15 events/hour, with >50% central events)
  • pregnancy
  • self-reported sleep duration less than 5 hours per night on weeknights (work nights)
  • current night shift work
  • pregnancy
  • self-reported sleep duration less than 5 hours per night on weeknights (work nights)
  • current night shift work

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 75 years old?

Where in Iceland

Also in 1 other country, 2 sites

  • University of IcelandReykjavik, IcelandContact: Thorarinn Gislason, MDTaking people

About the trial

What the trial wants to find out

Although obstructive sleep apnea (OSA) is a common disorder, there are no blood biomarkers for identification and management of these patients. This project will study microRNAs in order to develop and validate blood biomarkers that are specific to OSA, useful for identification of cases with OSA, reflective of efficacy of therapy, and able to predict blood pressure response to treatment of OSA.

The 2 groups in the trial

  • Cases

    Moderate-severe OSA (defined as AHI ≥15 events/hour)

    Treatment: Positive Airway Pressure

  • Controls

    No OSA (defined as AHI \<5 events/hour)

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Fit questions
Built from NCT06189755, who can take part
Record updated
3 August 2026