Breathing Machine Settings in Adults With Acute Brain Injury
Studies whether breathing machine settings relate to neurological status in adults with acute brain injury.
Plain-language title generated from the registry record
Registry title: Ventilatory Parameters in Acute Neurological Injury
Key facts
- Where
- Ciudad Autonoma de Buenos Aires, ArgentinaSee the site
Where in Argentina
- Roberto Santa CruzCiudad Autonoma de Buenos Aires, ArgentinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Ramos Mejía Hospital
- Trial code
- NCT06192342
- Record updated
- 27 August 2026
- Original description
The goal of this observational study is to test the association between baseline ventilatory parameters (in particular mechanical power (MP), mechanical power normalized to predicted body weight (MP/PBW) and driving pressure (DP) with the baseline neurological status (assessed through the Glasgow coma score) in adults patients under mechanical ventilation with acute neurological injury secondary to stroke, brain trauma or subarachnoid hemorrhage.Read full original descriptionShow less
Baseline Ventilatory Parameters in Patients With Acute Neurological Injury
The goal of this observational study is to test the association between baseline ventilatory parameters (in particular mechanical power (MP), mechanical power normalized to predicted body weight (MP/PBW) and driving pressure (DP) with the baseline neurological status (assessed through the Glasgow coma score) in adults patients under mechanical ventilation with acute neurological injury secondary to stroke, brain trauma or subarachnoid hemorrhage.
The main question[s]it aims to answer are:
1. In patients with acute neurological injury under mechanical ventilation, is there a correlation between the acute neurological injury, assessed using the Glasgow scale on admission, and baseline ventilatory parameters? 2. In patients with acute neurological injury under mechanical ventilation, are the baseline ventilatory parameters altered at baseline?
Inclusion: Acute neurological injury in patients ≥ 16 years of age with requiring mechanical ventilation for neurological causes and without baseline lung injury, defined as: normal chest x-ray and adequate oxygenation; PaO2/FiO2 ≥ 300.Neumovent TS and Neumovent Advance respirators will be used; -.
Exclusion: PaO2/FiO2 < 80 mmHg. Chronic obstructive pulmonary disease (COPD). Pregnant; Pneumothorax, or a pleural drainage tube. Hemodynamic instability (mean blood pressure ≤ 65 mmHg) or high doses of inotropes (Norepinephrine > 0.5 gammas/kilo/minute or equivalent).